美国匹兹堡大学Fadi G. Lakkis、Martin H. Oberbarnscheidt、康奈尔大学Xian C. Li等研究人员合作发现，PIR介导先天髓样细胞对非自身MHC分子的记忆。该研究于2020年5月7日在线发表于《科学》。

Title: PIRs mediate innate myeloid cell memory to nonself MHC molecules

Author: Hehua Dai, Peixiang Lan, Daqiang Zhao, Khodor Abou-Daya, Wentao Liu, Wenhao Chen, Andrew J. Friday, Amanda L. Williams, Tao Sun, Jianjiao Chen, Wei Chen, Steven Mortin-Toth, Jayne S. Danska, Chris Wiebe, Peter Nickerson, Tengfang Li, Lisa R. Mathews, Hêth R. Turnquist, Matthew L. Nicotra, Sebastien Gingras, Eiji Takayama, Hiromi Kubagawa, Mark J. Shlomchik, Martin H. Oberbarnscheidt, Xian C. Li, Fadi G. Lakkis

Issue&Volume: 2020/05/07

Abstract: Abstract Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. It is unknown however whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously upon subsequent encounters. Here, we show that murine monocytes and macrophages acquire memory specific to MHC-I antigens and identify paired immunoglobulin-like receptors-A (PIR-A) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.

DOI: 10.1126/science.aax4040

Source: https://science.sciencemag.org/content/early/2020/05/06/science.aax4040