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组织特异性药物递送的靶向策略
作者:小柯机器人 发布时间:2020/4/6 11:34:42

美国哈佛大学Samir Mitragotri等研究人总结了组织特异性药物递送的靶向策略。相关综述论文于2020年4月2日发表在《细胞》杂志上。

研究人员表示,在设计具有所需功效和可接受毒性的疗法时,全身性给药药物的脱靶效应一直是主要障碍。开发靶向策略以实现特定部位的药物递送有望减少脱靶效应,减少有害的毒性,从而增强药物的治疗功效。
 
在过去的三十年中,大量研究集中在理解阻碍组织特异性药物递送的生物学障碍以及研发克服这些障碍的策略。这些努力已在临床前和临床研究中产生了几种调节药物递送的靶向策略,包括基于小分子、核酸、肽、抗体和细胞的策略。
 
在这篇综述论文中,研究人员讨论了组织特异性药物递送的方法及其临床转化的关键进展和新兴概念。
 
附:英文原文

Title: Targeting Strategies for Tissue-Specific Drug Delivery

Author: Zongmin Zhao, Anvay Ukidve, Jayoung Kim, Samir Mitragotri

Issue&Volume: 2020/04/02

Abstract: Off-target effects of systemically administered drugs have been a major hurdle in designing therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to enable site-specific drug delivery holds promise in reducing off-target effects, decreasing unwanted toxicities, and thereby enhancing a drug’s therapeutic efficacy. Over the past three decades, a large body of literature has focused on understanding the biological barriers that hinder tissue-specific drug delivery and strategies to overcome them. These efforts have led to several targeting strategies that modulate drug delivery in both the preclinical and clinical settings, including small molecule-, nucleic acid-, peptide-, antibody-, and cell-based strategies. Here, we discuss key advances and emerging concepts for tissue-specific drug delivery approaches and their clinical translation.

DOI: 10.1016/j.cell.2020.02.001

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30145-8

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/