瑞士联邦理工学院Elisa Oricchio小组的最新研究发现，组织蛋白酶S调节非霍奇金淋巴瘤的抗原加工和T细胞活性。这一研究成果于2020年4月23日在线发表在《癌细胞》上。

Title: Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

Author: Elie Dheilly, Elena Battistello, Natalya Katanayeva, Stephanie Sungalee, Justine Michaux, Gerben Duns, Sarah Wehrle, Jessica Sordet-Dessimoz, Marco Mina, Julien Racle, Pedro Farinha, George Coukos, David Gfeller, Anja Mottok, Robert Kridel, Bruno E. Correia, Christian Steidl, Michal Bassani-Sternberg, Giovanni Ciriello, Vincent Zoete, Elisa Oricchio

Issue&Volume: 2020-04-23

Abstract: Genomic alterations in cancer cells can influence the immune system to favor tumorgrowth. In non-Hodgkin lymphoma, physiological interactions between B cells and thegerminal center microenvironment are coopted to sustain cancer cell proliferation.We found that follicular lymphoma patients harbor a recurrent hotspot mutation targetingtyrosine 132 (Y132D) in cathepsin S (CTSS) that enhances protein activity. CTSS regulatesantigen processing and CD4+ and CD8+ T cell-mediated immune responses. Loss of CTSS activity reduces lymphoma growth bylimiting communication with CD4+ T follicular helper cells while inducing antigen diversification and activation ofCD8+ T cells. Overall, our results suggest that CTSS inhibition has non-redundant therapeuticpotential to enhance anti-tumor immune responses in indolent and aggressive lymphomas.

DOI: 10.1016/j.ccell.2020.03.016

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30156-2