美国斯坦福大学鲍哲南与Paul M. George等研究人员合作取得一项新进展。他们开发了能够在生长组织中实现神经调节的形变电子器械。相关论文于2020年4月20日在线发表于《自然—生物技术》。
Title: Morphing electronics enable neuromodulation in growing tissue
Author: Yuxin Liu, Jinxing Li, Shang Song, Jiheong Kang, Yuchi Tsao, Shucheng Chen, Vittorio Mottni, Kelly McConnell, Wenhui Xu, Yu-Qing Zheng, Jeffrey B.-H. Tok, Paul M. George, Zhenan Bao
Abstract: Bioelectronics for modulating the nervous system have shown promise in treating neurological diseases1,2,3. However, their fixed dimensions cannot accommodate rapid tissue growth4,5 and may impair development6. For infants, children and adolescents, once implanted devices are outgrown, additional surgeries are often needed for device replacement, leading to repeated interventions and complications6,7,8. Here, we address this limitation with morphing electronics, which adapt to in vivo nerve tissue growth with minimal mechanical constraint. We design and fabricate multilayered morphing electronics, consisting of viscoplastic electrodes and a strain sensor that eliminate the stress at the interface between the electronics and growing tissue. The ability of morphing electronics to self-heal during implantation surgery allows a reconfigurable and seamless neural interface. During the fastest growth period in rats, morphing electronics caused minimal damage to the rat nerve, which grows 2.4-fold in diameter, and allowed chronic electrical stimulation and monitoring for 2 months without disruption of functional behavior. Morphing electronics offers a path toward growth-adaptive pediatric electronic medicine.