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鲍哲南团队合作开发调节神经的形变电子器械
作者:小柯机器人 发布时间:2020/4/21 14:09:01

美国斯坦福大学鲍哲南与Paul M. George等研究人员合作取得一项新进展。他们开发了能够在生长组织中实现神经调节的形变电子器械。相关论文于2020年4月20日在线发表于《自然—生物技术》。

研究人员表示,调节神经系统的生物电子器械已在治疗神经系统疾病中显示出希望。然而,它们的固定尺寸不能适应组织的快速生长,并且可能损害发育。对于婴儿、儿童和青少年,一旦植入的器械已不再适应,通常需要进行其他外科手术以更换器械,从而导致了反复的手术和并发症。
 
研究人员通过形变电子器械解决了这一局限,这些形变电子器械能够适应体内神经组织的生长并只有最小的机械约束。研究人员设计和制造多层形变电子器械,其由粘塑性电极和应变传感器组成,可消除电子器件与生长组织之间界面处的应力。
 
在植入手术中,电子器械能够通过形变来自我修复,从而实现了可重构且无缝的神经接口。在大鼠最快的生长期间,大鼠的神经直径能够增长2.4倍,但形变电子器械对大鼠神经造成的损害很小,并能够实现长期电刺激以及监测2个月而不会破坏功能行为。形变电子器械为适应成长的儿科电子医学提供了一条途径。
 
附:英文原文

Title: Morphing electronics enable neuromodulation in growing tissue

Author: Yuxin Liu, Jinxing Li, Shang Song, Jiheong Kang, Yuchi Tsao, Shucheng Chen, Vittorio Mottni, Kelly McConnell, Wenhui Xu, Yu-Qing Zheng, Jeffrey B.-H. Tok, Paul M. George, Zhenan Bao

Issue&Volume: 2020-04-20

Abstract: Bioelectronics for modulating the nervous system have shown promise in treating neurological diseases1,2,3. However, their fixed dimensions cannot accommodate rapid tissue growth4,5 and may impair development6. For infants, children and adolescents, once implanted devices are outgrown, additional surgeries are often needed for device replacement, leading to repeated interventions and complications6,7,8. Here, we address this limitation with morphing electronics, which adapt to in vivo nerve tissue growth with minimal mechanical constraint. We design and fabricate multilayered morphing electronics, consisting of viscoplastic electrodes and a strain sensor that eliminate the stress at the interface between the electronics and growing tissue. The ability of morphing electronics to self-heal during implantation surgery allows a reconfigurable and seamless neural interface. During the fastest growth period in rats, morphing electronics caused minimal damage to the rat nerve, which grows 2.4-fold in diameter, and allowed chronic electrical stimulation and monitoring for 2 months without disruption of functional behavior. Morphing electronics offers a path toward growth-adaptive pediatric electronic medicine.

DOI: 10.1038/s41587-020-0495-2

Source: https://www.nature.com/articles/s41587-020-0495-2

期刊信息

Nature Biotechnology:《自然—生物技术》,创刊于1996年。隶属于施普林格·自然出版集团,最新IF:31.864
官方网址:https://www.nature.com/nbt/
投稿链接:https://mts-nbt.nature.com/cgi-bin/main.plex