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研究发现Orexin信号调控雄性小鼠的攻击行为
作者:小柯机器人 发布时间:2020/4/19 23:07:45

美国西奈山伊坎医学院Scott J. Russo研究团队在研究中取得进展。他们的研究发现GABA能外侧缰核(LHb)神经元中的Orexin信号调控雄性小鼠的攻击行为。相关论文于2020413日发表在《自然-神经科学》杂志上。

他们表明,在雄性小鼠中,下丘脑外侧的Orexin神经元通过orexin受体2OxR2)激活了LHb中少量表达谷氨酸脱羧酶2GAD2)的神经元,并且该激活这些GAD2神经元中的一部分促进了雄性-雄性的攻击行为,并在侵略配对的环境中调节了位置偏好。

此外,LHb GAD2神经元在LHb内具有抑制作用,并从整体上抑制LHb的活性。这些结果表明,orexin系统对于调节雄性间的攻击行为很重要,并提供了LHb内局部抑制回路的第一个功能证据。

攻击性增强是多种神经精神疾病的特征,可能对患者,其家人和公众产生各种负面影响。最近在人和动物中进行的研究表明,攻击中涉及大脑奖励回路,并表明在好斗的个体的亚群中,对从属社会个体的控制正在增强。

附:英文原文

Title: Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice

Author: Meghan E. Flanigan, Hossein Aleyasin, Long Li, C. Joseph Burnett, Kenny L. Chan, Katherine B. LeClair, Elizabeth K. Lucas, Bridget Matikainen-Ankney, Romain Durand-de Cuttoli, Aki Takahashi, Caroline Menard, Madeline L. Pfau, Sam A. Golden, Sylvain Bouchard, Erin S. Calipari, Eric J. Nestler, Ralph J. DiLeone, Akihiro Yamanaka, George W. Huntley, Roger L. Clem, Scott J. Russo

Issue&Volume: 2020-04-13

Abstract: Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have various negative effects on patients, their families and the public. Recent studies in humans and animals have implicated brain reward circuits in aggression and suggest that, in subsets of aggressive individuals, domination of subordinate social targets is reinforcing. In this study, we showed that, in male mice, orexin neurons in the lateral hypothalamus activated a small population of glutamic acid decarboxylase 2 (GAD2)-expressing neurons in the lateral habenula (LHb) via orexin receptor 2 (OxR2) and that activation of these GAD2 neurons promoted male–male aggression and conditioned place preference for aggression-paired contexts. Moreover, LHb GAD2 neurons were inhibitory within the LHb and dampened the activity of the LHb as a whole. These results suggest that the orexin system is important for the regulation of inter-male aggressive behavior and provide the first functional evidence of a local inhibitory circuit within the LHb.

DOI: 10.1038/s41593-020-0617-7

Source: https://www.nature.com/articles/s41593-020-0617-7

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新if:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex