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研究揭示前运动皮质hand knob区域调控全身运动的机制
作者：小柯机器人 发布时间：2020/3/30 22:09:56

近日，美国斯坦福大学Francis R. Willett等研究人员揭示出前运动皮质hand knob区域调控全身运动的机制。这一研究成果于2020年3月26日在线发表在国际学术期刊《细胞》上。

使用多单元记录，研究人员探究了四肢瘫痪者的运动前皮层（中央回）hand knob区域中面部、头部、手臂和腿部运动如何表现。与传统观点相反，研究人员发现所有动作都有很强的表现，并且将所有四个肢体链接在一起的部分“组成”神经代码。
 
该代码由（1）代表要移动的肢体的肢体编码组件和（2）代表来自每个肢体的类似运动（例如，手抓和脚趾弯曲）的运动编码组件组成。合成编码可能有助于不同肢体的技能转移，这为思考运动系统如何构造运动提供了有用的框架。最后，研究人员利用这些结果创建了一个全身皮层内大脑-计算机界面，其可将目标分布在所有肢体上。
 
据悉，在首次提出“运动小人”（motor homunculus）概念之后数十年，人们仍不清楚在单个神经元分辨率下人体运动皮层区域中不同的身体部位如何相互混合以及相互关联。
 
附：英文原文

Title: Hand Knob Area of Premotor Cortex Represents the Whole Body in a Compositional Way

Author: Francis R. Willett, Darrel R. Deo, Donald T. Avansino, Paymon Rezaii, Leigh R. Hochberg, Jaimie M. Henderson, Krishna V. Shenoy

Issue&Volume: 2020-03-26

Abstract: Decades after the motor homunculus was first proposed, it is still unknown how different body parts are intermixed and interrelated in human motor cortical areas at single-neuron resolution. Using multi-unit recordings, we studied how face, head, arm, and leg movements are represented in the hand knob area of premotor cortex (precentral gyrus) in people with tetraplegia. Contrary to traditional expectations, we found strong representation of all movements and a partially “compositional” neural code that linked together all four limbs. The code consisted of (1) a limb-coding component representing the limb to be moved and (2) a movement-coding component where analogous movements from each limb (e.g., hand grasp and toe curl) were represented similarly. Compositional coding might facilitate skill transfer across limbs, and it provides a useful framework for thinking about how the motor system constructs movement. Finally, we leveraged these results to create a whole-body intracortical brain-computer interface that spreads targets across all limbs.

DOI: 10.1016/j.cell.2020.02.043

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30220-8

期刊信息
Cell：《细胞》，创刊于1974年。隶属于细胞出版社，最新IF：36.216
官方网址：https://www.cell.com/