英国剑桥大学Ziad Mallat研究小组发现，白介素33信号调控铁循环巨噬细胞的发育。相关论文于2020年4月8日在线发表在《免疫》杂志上。

Title: Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages

Author: Yuning Lu, Gemma Basatemur, Ian C. Scott, Davide Chiarugi, Marc Clement, James Harrison, Ravin Jugdaohsingh, Xian Yu, Stephen A. Newland, Helen E. Jolin, Xuan Li, Xiao Chen, Monika Szymanska, Guttorm Haraldsen, Gaby Palmer, Padraic G. Fallon, E. Suzanne Cohen, Andrew N.J. McKenzie, Ziad Mallat

Issue&Volume: 2020-04-08

Abstract: Splenic red pulp macrophages (RPMs) contribute to erythrocyte homeostasis and are required for iron recycling. Heme induces the expression of SPIC transcription factor in monocyte-derived macrophages and promotes their differentiation into RPM precursors, pre-RPMs. However, the requirements for differentiation into mature RPMs remain unknown. Here, we have demonstrated that interleukin (IL)-33 associated with erythrocytes and co-cooperated with heme to promote the generation of mature RPMs through activation of the MyD88 adaptor protein and ERK1/2 kinases downstream of the IL-33 receptor, IL1RL1. IL-33- and IL1RL1-deficient mice showed defective iron recycling and increased splenic iron deposition. Gene expression and chromatin accessibility studies revealed a role for GATA transcription factors downstream of IL-33 signaling during the development of pre-RPMs that retained full potential to differentiate into RPMs. Thus, IL-33 instructs the development of RPMs as a response to physiological erythrocyte damage with important implications to iron recycling and iron homeostasis.

DOI: 10.1016/j.immuni.2020.03.006

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30119-9