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科学家总结大麻使用障碍的神经生物学特征
作者:小柯机器人 发布时间:2020/4/10 13:17:19

美国纽约州伊坎医学院Yasmin L. Hurd研究组取得一项新突破。他们解构了大麻使用障碍的神经生物学。该成果发表在202046日出版的《自然-神经科学》杂志上。

大麻素受体介导大麻的作用,在已知介导与成瘾易感性有关的奖励、认知、情绪调节和应激反应的神经过程的大脑区域中大量表达。尽管存在关于使用大麻的潜在病理后果的争议,但大麻使用障碍是一种临床诊断症状,在普通人群中普遍流行,并且通常起源于青春期,并易感精神病合并症、遗传和环境因素有关的脆弱人群。

来自人类和动物研究的整合信息开始扩展关于与大麻使用障碍相关的神经生物学系统的认知,这些系统通常与其他物质使用障碍具有共同的神经特征,可以为预防和治疗策略提供参考。

据悉,全球对娱乐和医疗大麻的态度和消费情况发生了巨大变化。

附:英文原文

Title: Deconstructing the neurobiology of cannabis use disorder

Author: Jacqueline-Marie N. Ferland, Yasmin L. Hurd

Issue&Volume: 2020-04-06

Abstract: There have been dramatic changes worldwide in the attitudes toward and consumption of recreational and medical cannabis. Cannabinoid receptors, which mediate the actions of cannabis, are abundantly expressed in brain regions known to mediate neural processes underlying reward, cognition, emotional regulation and stress responsivity relevant to addiction vulnerability. Despite debates regarding potential pathological consequences of cannabis use, cannabis use disorder is a clinical diagnosis with high prevalence in the general population and that often has its genesis in adolescence and in vulnerable individuals associated with psychiatric comorbidity, genetic and environmental factors. Integrated information from human and animal studies is beginning to expand insights regarding neurobiological systems associated with cannabis use disorder, which often share common neural characteristics with other substance use disorders, that could inform prevention and treatment strategies.

DOI: 10.1038/s41593-020-0611-0

Source: https://www.nature.com/articles/s41593-020-0611-0

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新if:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex