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沃尔巴氏菌感染的雄性埃及伊蚊可大规模抑制其野生种群
作者:小柯机器人 发布时间:2020/4/10 10:24:46

美国Verily生命科学公司Bradley J. White和Jacob E. Crawford研究小组取得进展。他们的研究显示,高效生产沃尔巴氏菌感染的雄性埃及伊蚊(Aedes aegypti),可大规模抑制其野生种群。2020年4月6日,该成果在线发表在《自然-生物技术》杂志上。

研究人员利用自动化工程产生和释放了数百万只竞争性、不育的沃尔巴氏菌感染的雄性蚊子,并在加利福尼亚州弗雷斯诺县进行的大规模镇压试验中使用了这些雄性蚊子。2018年,研究人员在三个重复的地区(占地293公顷)释放了1,440万雄性蚊虫。

在蚊子旺季,与非释放地区相比,释放地区的雌性蚊子数量减少了95.5%(95%CI,93.6–96.9),而在地理上最孤立的地区可减少99%。这项工作证明了蚊子昆虫不育技术可以在比之前类似试验大9倍的区域内具有很高的功效,同时支持了昆虫不育技术在公共卫生和消除蚊子滋生计划中的潜力。

据悉,埃及伊蚊的范围不断扩大,使超过二十亿人面临虫媒病毒感染的危险。昆虫不育技术(SIT)已大规模成功抵抗了农业害虫,但其没使蚊子灭绝,这主要因为面临着高品质雄性蚊子不断生产和分布广泛的挑战。

据:英文原文

Title: Efficient production of male Wolbachia -infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations

Author: Jacob E. Crawford, David W. Clarke, Victor Criswell, Mark Desnoyer, Devon Cornel, Brittany Deegan, Kyle Gong, Kaycie C. Hopkins, Paul Howell, Justin S. Hyde, Josh Livni, Charlie Behling, Renzo Benza, Willa Chen, Karen L. Dobson, Craig Eldershaw, Daniel Greeley, Yi Han, Bridgette Hughes, Evdoxia Kakani, Joe Karbowski, Angus Kitchell, Erika Lee, Teresa Lin, Jianyi Liu, Martin Lozano, Warren MacDonald, James W. Mains, Matty Metlitz, Sara N. Mitchell, David Moore, Johanna R. Ohm, Kathleen Parkes, Alexandra Porshnikoff, Chris Robuck, Martin Sheridan, Robert Sobecki, Peter Smith, Jessica Stevenson, Jordan Sullivan, Brian Wasson, Allison M. Weakley, Mark Wilhelm, Joshua Won, Ari Yasunaga, William C. Chan, Jodi Holeman, Nigel Snoad, Linus Upson, Tiantian Zha, Stephen L. Dobson, F. Steven Mulligan, Peter Massaro, Bradley J. White

Issue&Volume: 2020-04-06

Abstract: The range of the mosquito Aedes aegypti continues to expand, putting more than two billion people at risk of arboviral infection. The sterile insect technique (SIT) has been used to successfully combat agricultural pests at large scale, but not mosquitoes, mainly because of challenges with consistent production and distribution of high-quality male mosquitoes. We describe automated processes to rear and release millions of competitive, sterile male Wolbachia-infected mosquitoes, and use of these males in a large-scale suppression trial in Fresno County, California. In 2018, we released 14.4 million males across three replicate neighborhoods encompassing 293 hectares. At peak mosquito season, the number of female mosquitoes was 95.5% lower (95% CI, 93.6–96.9) in release areas compared to non-release areas, with the most geographically isolated neighborhood reaching a 99% reduction. This work demonstrates the high efficacy of mosquito SIT in an area ninefold larger than in previous similar trials, supporting the potential of this approach in public health and nuisance-mosquito eradication programs.

DOI: 10.1038/s41587-020-0471-x

Source: https://www.nature.com/articles/s41587-020-0471-x

期刊信息

Nature Biotechnology:《自然—生物技术》,创刊于1996年。隶属于施普林格·自然出版集团,最新IF:31.864
官方网址:https://www.nature.com/nbt/
投稿链接:https://mts-nbt.nature.com/cgi-bin/main.plex