近日，美国密歇根大学医学院齐岭（Ling Qi）及其团队发现，内质网（ER）相关降解参与调控棕色脂肪细胞的线粒体动态。相关论文于2020年3月20日在线发表在《科学》。

Title: Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes

Author: Zhangsen Zhou, Mauricio Torres, Haibo Sha, Christopher J. Halbrook, Franoise Van den Bergh, Rachel B. Reinert, Tatsuya Yamada, Siwen Wang, Yingying Luo, Allen H. Hunter, Chunqing Wang, Thomas H. Sanderson, Meilian Liu, Aaron Taylor, Hiromi Sesaki, Costas A. Lyssiotis, Jun Wu, Sander Kersten, Daniel A. Beard, Ling Qi

Issue&Volume: 2020/03/19

Abstract: AbstractThe endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic “megamitochondria” with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice with ERAD deficiency in brown adipocytes were cold sensitive and exhibited mitochondrial dysfunction. ERAD deficiency affected ER-mitochondria contacts and mitochondrial dynamics, at least in part, by regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1). Thus, our study provides molecular insights into ER-mitochondrial crosstalk and expands our understanding of the physiological importance of Sel1L-Hrd1 ERAD.

DOI: 10.1126/science.aay2494

Source: https://science.sciencemag.org/content/early/2020/03/18/science.aay2494