加拿大英属哥伦比亚大学Fabio M.V. Rossi研究团队揭示了表达Hic1的心脏基质祖细胞的致病潜力。2020年1月23日，国际知名学术期刊《细胞—干细胞》在线发表了这一成果。
Title: Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors
Author: Hesham Soliman, Ben Paylor, R. Wilder Scott, Dario R. Lemos, ChihKai Chang, Martin Arostegui, Marcela Low, Christina Lee, Daniela Fiore, Paola Braghetta, Vendula Pospichalova, Christina E. Barkauskas, Vladimir Korinek, Alessandra Rampazzo, Kathleen MacLeod, T. Michael Underhill, Fabio M.V. Rossi
Issue&Volume: January 23, 2020
Abstract: The cardiac stroma contains multipotent mesenchymal progenitors. However, lineagerelationships within cardiac stromal cells are poorly defined. Here, we identifiedheart-resident PDGFRa+ SCA-1+ cells as cardiac fibro/adipogenic progenitors (cFAPs) and show that they respondto ischemic damage by generating fibrogenic cells. Pharmacological blockade of thisdifferentiation step with an anti-fibrotic tyrosine kinase inhibitor decreases post-myocardialinfarction (post-MI) remodeling and leads to improvement in cardiac function. In theundamaged heart, activation of cFAPs through lineage-specific deletion of the geneencoding the quiescence-associated factor HIC1 reveals additional pathogenic potential,causing fibrofatty infiltration within the myocardium and driving major pathologicalfeatures pathognomonic in arrhythmogenic cardiomyopathy (AC). In this regard, cFAPscontribute to multiple pathogenic cell types within cardiac tissue and therapeuticstrategies aimed at modifying their activity are expected to have tremendous benefitfor the treatment of diverse cardiac diseases.
Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：21.464