近日，中南大学湘雅医院罗湘杭、美国爱因斯坦医学院蔡东升等研究人员合作发现，减少下丘脑干细胞衰老防止衰老相关的生理变化。2020年1月30日，国际知名学术期刊《细胞—代谢》在线发表了这一成果。

Title: Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

Author: Yu-Zhong Xiao, Mi Yang, Ye Xiao, Qi Guo, Yan Huang, Chang-Jun Li, Dongsheng Cai, Xiang-Hang Luo

Issue&Volume: January 30, 2020

Abstract: Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for thepathological consequences of aging; however, it is unclear what drives the senescenceof htNSCs. Here, we report that a long non-coding RNA, Hnscr, is abundantly expressed in the htNSCs of young mice but decreases markedly in middle-agedmice. We show that depletion of Hnscr is sufficient to drive the senescence of htNSCs and aging-like phenotypes in mice.Mechanistically, Hnscr binds to Y-box protein 1 (YB-1) to prevent its degradation and thus the attenuationof transcription of the senescence marker gene p16INK4A. Through molecular docking, we discovered that a naturally occurring small compound,theaflavin 3-gallate, can mimic the activity of Hnscr. Treatment of middle-aged mice with theaflavin 3-gallate reduced the senescence ofhtNSCs while improving aging-associated pathology. These results point to a mediatorof the aging process and one that can be pharmacologically targeted to improve aging-relatedoutcomes.

DOI: 10.1016/j.cmet.2020.01.002

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30002-4