荷兰莱顿大学医学中心Meta Roestenberg小组近日取得一项新成果。他们开发出一种可控制的人类曼氏血吸虫感染模型,可用于开发新药、疫苗和诊断方法。相关论文2020年2月17日在线发表于《自然—医学》杂志。
Title: A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics
Author: Marijke C. C. Langenberg, Marie-Astrid Hoogerwerf, Jan Pieter R. Koopman, Jacqueline J. Janse, Janneke Kos-van Oosterhoud, Carola Feijt, Simon P. Jochems, Claudia J. de Dood, Roos van Schuijlenburg, Arifa Ozir-Fazalalikhan, Mikhael D. Manurung, Erliyani Sartono, Martha T. van der Beek, Batrice M. F. Winkel, Petra H. Verbeek-Menken, Koen A. Stam, Fijs W. B. van Leeuwen, Pauline Meij, Angela van Diepen, Lisette van Lieshout, Govert J. van Dam, Paul L. A. M. Corstjens, Cornelis H. Hokke, Maria Yazdanbakhsh, Leo G. Visser, Meta Roestenberg
Issue&Volume: 2020-02-17
Abstract: Schistosomiasis treatment relies on the use of a single drug, praziquantel, which is insufficient to control transmission in highly endemic areas1. Novel medicines and vaccines are urgently needed2,3. An experimental human model for schistosomiasis could accelerate the development of these products. We performed a dose-escalating clinical safety trial in 17 volunteers with male Schistosoma mansoni cercariae, which do not produce eggs (clinicaltrials.gov NCT02755324), at the Leiden University Medical Center, the Netherlands. The primary endpoints were adverse events and infectivity. We found a dose-related increase in adverse events related to acute schistosomiasis syndrome, which occurred in 9 of 17 volunteers. Overall, 5 volunteers (all 3 of the high dose group and 2 of 11 of the medium dose group) reported severe adverse events. Worm-derived circulating anodic antigen, the biomarker of the primary infection endpoint, peaked in 82% of volunteers at 3–10 weeks following exposure. All volunteers showed IgM and IgG1 seroconversion and worm-specific cytokine production by CD4+ T cells. All volunteers were cured with praziquantel provided at 12 weeks after exposure. Infection with 20 Schistosoma mansoni cercariae led to severe adverse events in 18% of volunteers and high infection rates. This infection model paves the way for fast-track product development for treatment and prevention of schistosomiasis.
DOI: 10.1038/s41591-020-0759-x
Source: https://www.nature.com/articles/s41591-020-0759-x
Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex