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记忆抑制在精神创伤恢复中的作用
作者:小柯机器人 发布时间:2020/2/17 13:33:35

法国巴黎文理研究型大学Pierre Gagnepain团队的最新工作揭示了记忆抑制在精神创伤恢复中的作用。2020年2月14日,国际知名学术期刊《科学》发表了这一成果。

研究人员在实验室中对102名经历2015年巴黎恐怖袭击的个人和73名未经历的个人(在袭击期间不在巴黎)测试了中性和非冒犯的闯入记忆。在重新体验这些闯入记忆时,未经历的个体和没有创伤后应激障碍(PTSD)的经历个体可以自适应地抑制记忆活动,而患有PTSD的经历个体则不能。这些发现表明,抑制记忆的能力对于积极的创伤后适应至关重要。记忆控制系统的一般性中断能够解释PTSD患者中经常出现的适应不良和抑制失败,并且这种中断应使用特定的疗法进行干预。
 
据悉,目前对于为什么某些人会在经历创伤之后持续产生不必要且无法避免的回忆仍了解甚少。
 
附:英文原文

Title: Resilience after trauma: The role of memory suppression

Author: Alison Mary, Jacques Dayan, Giovanni Leone, Charlotte Postel, Florence Fraisse, Carine Malle, Thomas Vallée, Carine Klein-Peschanski, Fausto Viader, Vincent de la Sayette, Denis Peschanski, Francis Eustache, Pierre Gagnepain

Issue&Volume: 2020/02/14

Abstract: In the aftermath of trauma, little is known about why the unwanted and unbidden recollection of traumatic memories persists in some individuals but not others. We implemented neutral and inoffensive intrusive memories in the laboratory in a group of 102 individuals exposed to the 2015 Paris terrorist attacks and 73 nonexposed individuals, who were not in Paris during the attacks. While reexperiencing these intrusive memories, nonexposed individuals and exposed individuals without posttraumatic stress disorder (PTSD) could adaptively suppress memory activity, but exposed individuals with PTSD could not. These findings suggest that the capacity to suppress memory is central to positive posttraumatic adaptation. A generalized disruption of the memory control system could explain the maladaptive and unsuccessful suppression attempts often seen in PTSD, and this disruption should be targeted by specific treatments.

DOI: 10.1126/science.aay8477

Source: https://science.sciencemag.org/content/367/6479/eaay8477

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037