中国第三军医大学Feng Mei、美国加州大学旧金山分校Jonah R. Chan等研究人员合作发现，髓鞘质变性和髓鞘更新减少导致衰老相关的记忆缺陷。相关论文于2020年2月10日在线发表在《自然—神经科学》上。
Title: Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory
Author: Fei Wang, Shu-Yu Ren, Jing-Fei Chen, Kun Liu, Rui-Xue Li, Zhi-Fang Li, Bo Hu, Jian-Qin Niu, Lan Xiao, Jonah R. Chan, Feng Mei
Abstract: Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.