美国杜克大学医学中心Terry Lechler小组发现，分化的子细胞通过组织内张力调节干细胞的增殖和命运。2020年12月1日，国际知名学术期刊《细胞—干细胞》在线发表了这一成果。

研究人员发现，基底祖细胞的分化后代参与调节基底祖细胞的增殖、分化和迁移。使用两种不同的小鼠品系，研究人员发现分化细胞的收缩力增加导致干细胞非细胞自主过度增殖，并阻止了它们对毛囊谱系的转换。这种增加的可收缩性还损害了在头发斑块形态发生期间基底祖细胞的运动，并减少了黑素细胞的迁移。

这些数据表明组织内张力调节干细胞增殖、命运决定和迁移，并且分化的表皮角质形成细胞是调节皮肤发育和动态平衡的干细胞微环境的组成部分。

据了解，基底干细胞促进表皮的发育、体内平衡和再生。这些细胞的增殖和命运决定受到它们微环境的高度调节，包括基底膜和下面的间充质细胞。基底祖细胞引起分化的后代，从而产生表皮屏障。

附：英文原文

Title: Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension

Author: Wenxiu Ning, Andrew Muroyama, Hua Li, Terry Lechler

Issue&Volume: 2020-12-01

Abstract: Basal stem cells fuel development, homeostasis, and regeneration of the epidermis.The proliferation and fate decisions of these cells are highly regulated by theirmicroenvironment, including the basement membrane and underlying mesenchymal cells.Basal progenitors give rise to differentiated progeny that generate the epidermalbarrier. Here, we present data that differentiated progeny also regulate the proliferation,differentiation, and migration of basal progenitor cells. Using two distinct mouselines, we found that increasing contractility of differentiated cells resulted innon-cell-autonomous hyperproliferation of stem cells and prevented their commitmentto a hair follicle lineage. This increased contractility also impaired movement ofbasal progenitors during hair placode morphogenesis and diminished migration of melanoblasts.These data suggest that intra-tissue tension regulates stem cell proliferation, fatedecisions, and migration and that differentiated epidermal keratinocytes are a componentof the stem cell niche that regulates development and homeostasis of the skin.

DOI: 10.1016/j.stem.2020.11.002

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30540-3