重庆医科大学黄爱龙等研究人员合作报道了SARS-CoV-2在中国万州传播的有效控制措施。相关论文于2020年11月30日在线发表在《自然—医学》杂志上。

研究人员评估了中国万州COVID-19控制措施的有效性。在万州整个COVID-19暴发期间，研究人员分析了183例确诊的COVID-19病例及其密切接触者的流行病学数据，这些病例来自5代的SARS-CoV-2传播。有症状和无症状的病例分别约为67.2％和32.8％。无症状和症状前传播占记录传播总数的75.9％。

G1-G2传播的基本再生数为1.64（95％置信区间：1.16-2.40），在后代中降低到0.31-0.39，同时实施了严格的控制措施。在感染后5天内，与被感染者接触、频繁接触以及超过8小时接触，都具有明显较高的感染风险。通过社交隔离、广泛的接触者追踪、大规模测试和严格的近距离隔离，该传播链被打破，并有效地控制了COVID-19在万州的传播。

附：英文原文

Title: Effective control of SARS-CoV-2 transmission in Wanzhou, China

Author: Qiuling Shi, Yaoyue Hu, Bin Peng, Xiao-Jun Tang, Wei Wang, Kun Su, Chao Luo, Bo Wu, Fan Zhang, Yong Zhang, Benjamin Anderson, Xiao-Ni Zhong, Jing-Fu Qiu, Cheng Yong Yang, Ai-Long Huang

Issue&Volume: 2020-11-30

Abstract: The effectiveness of control measures to contain coronavirus disease 2019 (COVID-19) in Wanzhou, China was assessed. Epidemiological data were analyzed for 183 confirmed COVID-19 cases and their close contacts from five generations of transmission of severe acute respiratory syndrome coronavirus 2 throughout the entire COVID-19 outbreak in Wanzhou. Approximately 67.2% and 32.8% of cases were symptomatic and asymptomatic, respectively. Asymptomatic and presymptomatic transmission accounted for 75.9% of the total recorded transmission. The reproductive number was 1.64 (95% confidence interval: 1.16–2.40) for G1-to-G2 transmission, decreasing to 0.31–0.39 in later generations, concomitant with implementation of rigorous control measures. Substantially higher infection risk was associated with contact within 5d after the infectors had been infected, frequent contact and ≥8h of contact duration. The spread of COVID-19 was effectively controlled in Wanzhou by breaking the transmission chain through social distancing, extensive contact tracing, mass testing and strict quarantine of close contacts.

DOI: 10.1038/s41591-020-01178-5

Source: https://www.nature.com/articles/s41591-020-01178-5