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海马位置细胞的靶向激活驱动记忆引导的空间行为
作者:小柯机器人 发布时间:2020/11/9 22:21:00

英国伦敦大学学院Michael Häusser、Nick T.M. Robinson等研究人员合作发现,海马位置细胞的靶向激活驱动记忆引导的空间行为。2020年11月6日,《细胞》在线发表了这一成果。

通过同时进行双光子钙成像和双光子光遗传学的“全光学”组合,研究人员鉴定并选择性激活了编码虚拟现实环境中行为相关位置的细胞。在空间记忆任务期间,对少量位置细胞的靶向刺激足以使动物的行为产生偏差,这提供了海马位置细胞主动支持空间导航和记忆的因果证据。
 
据介绍,海马对于空间导航和情景记忆形成至关重要。海马位置细胞在环境中表现出空间选择性的活动,并被认为能够形成空间认知地图的神经基础,从而支持这些记忆功能。但是,尚未证明位置单元活动对空间导航行为的直接影响。
 
附:英文原文

Title: Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior

Author: Nick T.M. Robinson, Lucie A.L. Descamps, Lloyd E. Russell, Moritz O. Buchholz, Brendan A. Bicknell, Georgy K. Antonov, Joanna Y.N. Lau, Rebecca Nutbrown, Christoph Schmidt-Hieber, Michael Husser

Issue&Volume: 2020-11-06

Abstract: The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activity on spatial navigation behavior has not yet been demonstrated. Using an ‘all-optical’ combination of simultaneous two-photon calcium imaging and two-photon optogenetics, we identified and selectively activated place cells that encoded behaviorally relevant locations in a virtual reality environment. Targeted stimulation of a small number of place cells was sufficient to bias the behavior of animals during a spatial memory task, providing causal evidence that hippocampal place cells actively support spatial navigation and memory.

DOI: 10.1016/j.cell.2020.09.061

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31302-7

期刊信息
Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/