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研究揭示人类中已有的和从头的SARS-CoV-2体液免疫
作者：小柯机器人 发布时间：2020/11/9 22:12:02

英国弗朗西斯·克里克研究所George Kassiotis等研究人员合作揭示了人类中已有的和从头的SARS-CoV-2体液免疫。2020年11月6日，《科学》杂志在线发表了这项成果。

使用SARS-CoV-2蛋白识别抗体的多种检测方法，研究人员可以检测到以前存在的体液免疫。通过基于流式细胞术的方法，研究人员在未感染SARS-CoV-2的个体中检测到了SARS-CoV-2突刺糖蛋白（S）反应性抗体，并且在儿童和青少年中特别普遍。它们主要是IgG类，并靶向S2亚基。
 
相比之下，SARS-CoV-2感染可诱导更高滴度的SARS-CoV-2 S反应性IgG抗体，既靶向S1和S2亚基，也伴随IgM和IgA抗体，持续整个观察期。
 
值得注意的是，未感染SARS-CoV-2的供体血清对SARS-CoV-2和SARS-CoV-2 S假型表现出特定的中和活性。区分以前存在的和从头的免疫对于人们理解SARS-CoV-2感染的易感性和自然过程至关重要。
 
据悉，新型冠状病毒的传播可能会在人类中遇到以前存在的免疫力。 
 
附：英文原文

Title: Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Author: Kevin W. Ng, Nikhil Faulkner, Georgina H. Cornish, Annachiara Rosa, Ruth Harvey, Saira Hussain, Rachel Ulferts, Christopher Earl, Antoni G. Wrobel, Donald J. Benton, Chloe Roustan, William Bolland, Rachael Thompson, Ana Agua-Doce, Philip Hobson, Judith Heaney, Hannah Rickman, Stavroula Paraskevopoulou, Catherine F. Houlihan, Kirsty Thomson, Emilie Sanchez, Gee Yen Shin, Moira J. Spyer, Dhira Joshi, Nicola O’Reilly, Philip A. Walker, Svend Kjaer, Andrew Riddell, Catherine Moore, Bethany R. Jebson, Meredyth Wilkinson, Lucy R. Marshall, Elizabeth C. Rosser, Anna Radziszewska, Hannah Peckham, Coziana Ciurtin, Lucy R. Wedderburn, Rupert Beale, Charles Swanton, Sonia Gandhi, Brigitta Stockinger, John McCauley, Steve J. Gamblin, Laura E. McCoy, Peter Cherepanov, Eleni Nastouli

Issue&Volume: 2020/11/06

Abstract: AbstractZoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detect preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)-reactive antibodies were detectable by a flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents. They were predominantly of the IgG class and targeted the S2 subunit. By contrast, SARS-CoV-2 infection induced higher titers of SARS-CoV-2 S-reactive IgG antibodies, targeting both the S1 and S2 subunits, and concomitant IgM and IgA antibodies, lasting throughout the observation period. Notably, SARS-CoV-2-uninfected donor sera exhibited specific neutralizing activity against SARS-CoV-2 and SARS-CoV-2 S pseudotypes. Distinguishing preexisting and de novo immunity will be critical for our understanding of susceptibility to and the natural course of SARS-CoV-2 infection.

DOI: 10.1126/science.abe1107

Source: https://science.sciencemag.org/content/early/2020/11/05/science.abe1107

期刊信息
Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037