美国斯坦福大学Onn Brandman研究团队发现,温度和能量可用性调控细胞粘度。这一研究成果于2020年11月5日在线发表在《细胞》上。
Title: Cellular Control of Viscosity Counters Changes in Temperature and Energy Availability
Author: Laura B. Persson, Vardhaan S. Ambati, Onn Brandman
Issue&Volume: 2020-11-05
Abstract: Cellular functioning requires the orchestration of thousands of molecular interactionsin time and space. Yet most molecules in a cell move by diffusion, which is sensitiveto external factors like temperature. How cells sustain complex, diffusion-based systemsacross wide temperature ranges is unknown. Here, we uncover a mechanism by which buddingyeast modulate viscosity in response to temperature and energy availability. This“viscoadaptation” uses regulated synthesis of glycogen and trehalose to vary the viscosityof the cytosol. Viscoadaptation functions as a stress response and a homeostatic mechanism,allowing cells to maintain invariant diffusion across a 20°C temperature range. Perturbationsto viscoadaptation affect solubility and phase separation, suggesting that viscoadaptationmay have implications for multiple biophysical processes in the cell. Conditions thatlower ATP trigger viscoadaptation, linking energy availability to rate regulationof diffusion-controlled processes. Viscoadaptation reveals viscosity to be a tunableproperty for regulating diffusion-controlled processes in a changing environment.
DOI: 10.1016/j.cell.2020.10.017
Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31380-5