中科院兰州化学物理研究所羰基合成与选择氧化国家重点实验室徐森苗团队，在直链酰胺上的亚甲基β-C(sp³)-H键不对称硼化反应研究方面取得新进展。2020年11月4日，《德国应用化学》发表了这一成果。

课题组人员首次报道了直链酰胺上无差别的亚甲基β-C(sp³)-H键的直接手性选择性硼化反应，该反应是由铱催化并受酰胺键引导的。这一反应成功的关键在于精心选择含铱前体和手性双齿含硼配体的组合。该反应对不同官能团的普适性较好，生成的手性β-取代的酰胺具有良好至优秀的光学选择性。

利用这一反应，课题组还进一步展示了将碳-硼键立体选择性地转化为其他官能团。

附：英文原文

Title: Iridium‐Catalyzed Enantioselective Unbiased Methylene C(sp3)‐H Borylation of Acyclic Amides

Author: Yuhuan Yang, Lili Chen, Senmiao Xu

Issue&Volume:04 November 2020

Abstract: We herein report amide directed enantioselective β‐C(sp  3  )‐H borylation of unbiased methylene C‐H bonds of acyclic amides enabled by iridium catalysis for the first time. The key to the success of this transformation relies on the careful selection of the combination of iridium precursor and chiral bidentate boryl ligands. A variety of functional groups are well‐tolerated, affording chiral β‐functionalized amides in good to excellent enantioselectivities. We also demonstrate the application of the current method by stereospecific conversion of C‐B bond into other functionalities.

DOI: 10.1002/anie.202013568

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202013568