华中科技大学汪道文团队发现,胰岛素治疗与COVID-19患者的死亡率增加相关。这一研究成果于2020年11月23日在线发表在国际学术期刊《细胞—代谢》上。
Title: Insulin treatment is associated with increased mortality in patients with COVID-19
Author: Bo Yu, Chenze Li, Yang Sun, Dao Wen Wang
Issue&Volume: 2020-11-23
Abstract: COVID-19 caused by SARS-COV2 infection can lead to multi-organ injuries and significant mortality in severe and critical patients, especially among those individuals with type 2 diabetes (T2D) as a comorbidity. While attenuated mortality was observed with aggressive glucose control, it was unclear whether therapeutic regiments including insulin treatment was beneficial for patients with COVID-19 and T2D. This retrospective study investigated 689 patients with COVID-19 and T2D from a cohort of 3,305 cases from Wuhan, China. Unexpectedly, we found that insulin treatment for patients with COVID-19 and T2D was associated with a significant increase in mortality [27.2% vs. 3.5%; adjusted HR, 5.38 (2.75-10.54)]. Further analysis showed that insulin treatment was associated with enhanced systemic inflammation and aggravated injuries of vital organs. Therefore, insulin treatment for patients with COVID-19 and T2D should be used with caution.
DOI: 10.1016/j.cmet.2020.11.014
Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30647-1
Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:22.415
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