法国巴斯德研究所Louis Lambrechts团队的最新研究表明埃及伊蚊的全球入侵增了强寨卡病毒的敏感性。该研究于2020年11月20日发表于国际学术期刊《科学》。

研究人员发现人类的特殊化和埃及伊蚊的随后传播，伴随着其获取和传播新兴人类病原体寨卡病毒内在能力的增强。因此，埃及伊蚊的最近进化和全球扩张不仅是通过增加载体与宿主的接触，而且还增强了载体的敏感性而促进了虫媒病毒的出现。

据介绍，人们对人畜共患病毒出现的原因和模式知之甚少。埃及伊蚊（Aedes aegypti）是一种主要的虫媒病毒载体，起源于非洲，在过去的四个世纪中，它入侵了世界上大多数的热带地区，这是一种“驯化”形式的演变，这种形式专门用于叮人和在储水容器中繁殖。

附：英文原文

Title: Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations

Author: Fabien Aubry, Stéphanie Dabo, Caroline Manet, Igor Filipovi, Noah H. Rose, Elliott F. Miot, Daria Martynow, Artem Baidaliuk, Sarah H. Merkling, Laura B. Dickson, Anna B. Crist, Victor O. Anyango, Claudia M. Romero-Vivas, Anubis Vega-Rúa, Isabelle Dusfour, Davy Jiolle, Christophe Paupy, Martin N. Mayanja, Julius J. Lutwama, Alain Kohl, Veasna Duong, Alongkot Ponlawat, Massamba Sylla, Jewelna Akorli, Sampson Otoo, Joel Lutomiah, Rosemary Sang, John-Paul Mutebi, Van-Mai Cao-Lormeau, Richard G. Jarman, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Carolyn S. McBride, Xavier Montagutelli, Gordana Rai, Louis Lambrechts

Issue&Volume: 2020/11/20

Abstract: The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world’s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.

DOI: 10.1126/science.abd3663

Source: https://science.sciencemag.org/content/370/6519/991