当前位置:科学网首页 > 小柯机器人 >详情
微生物来源的抗真菌药可杀伤高威胁性耐药真菌
作者:小柯机器人 发布时间:2020/11/22 1:25:52

美国威斯康星大学麦迪逊分校Tim S. Bugni和David R. Andes研究小组合作取得一项新成果。他们发现从海洋微生物提取的抗真菌药可杀伤高威胁性耐药真菌。相关论文于2020年11月20日发表于国际学术期刊《科学》。

利用海洋动物微生物群以及先进代谢组学和基因组学相结合的方法,研究人员发现了具有体内功效的抗真菌分子。最有成药潜能的是turbinmicin,其对多种耐药性真菌病原体显示出有效的体外和小鼠模型功效,并具有广泛的安全指数,其通过针对囊泡运输途径Sec14的真菌特异性作用方式发挥功能。与其他抗真菌药不同的功效、安全性和作用方式,使的turbinmicin成为一种很有潜能的抗真菌药,可帮助解决毁灭性的全球真菌病原体,例如耳念珠菌。

据介绍,迫切需要新的抗真菌药物来解决真菌感染性疾病(如泛耐药性耳念珠菌)的发生和跨地区性传播。

附:英文原文

Title: A marine microbiome antifungal targets urgent-threat drug-resistant fungi

Author: Fan Zhang, Miao Zhao, Doug R. Braun, Spencer S. Ericksen, Jeff S. Piotrowski, Justin Nelson, Jian Peng, Gene E. Ananiev, Shaurya Chanana, Kenneth Barns, Jen Fossen, Hiram Sanchez, Marc G. Chevrette, Ilia A. Guzei, Changgui Zhao, Le Guo, Weiping Tang, Cameron R. Currie, Scott R. Rajski, Anjon Audhya, David R. Andes, Tim S. Bugni

Issue&Volume: 2020/11/20

Abstract: New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug–resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as C. auris.

DOI: 10.1126/science.abd6919

Source: https://science.sciencemag.org/content/370/6519/974

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037