美国加州大学洛杉矶分校Brigitte N. Gomperts等研究人员合作发现，直接暴露SARS-CoV-2和香烟烟雾会增加感染的严重程度并改变干细胞来源的气道修复反应。相关论文于2020年11月17日在线发表于国际学术期刊《细胞—干细胞》。
Title: Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response
Author: Arunima Purkayastha, Chandani Sen, Gustavo Garcia, Justin Langerman, David W. Shia, Luisa K. Meneses, Preethi Vijayaraj, Abdo Durra, Caroline R. Koloff, Delilah R. Freund, Justin Chi, Tammy M. Rickabaugh, Apoorva Mulay, Bindu Konda, Myung S. Sim, Barry R. Stripp, Kathrin Plath, Vaithilingaraja Arumugaswami, Brigitte N. Gomperts
Abstract: Current smoking is associated with increased risk of severe COVID-19 but it is not clear how cigarette smoke (CS) exposure affects SARS-CoV-2 airway cell infection. We directly exposed air-liquid interface (ALI) cultures derived from primary human nonsmoker airway basal stem cells (ABSCs) to short term CS and then infected them with SARS-CoV-2. We found an increase in the number of infected airway cells after CS exposure with a lack of ABSC proliferation. Single cell profiling of the cultures showed that the normal interferon response was reduced after CS exposure with infection. Treatment of CS-exposed ALI cultures with Interferon β-1 abrogated the viral infection, suggesting one potential mechanism for more severe viral infection. Our data show that acute CS exposure allows for more severe airway epithelial disease from SARS-CoV-2 by reducing the innate immune response and ABSC proliferation and has implications for disease spread and severity in people exposed to CS.
Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：21.464