德国欧洲分子生物学实验室Alba Diz-Muoz小组发现，细胞表面力学调控胚胎干细胞的分化。2020年11月17日，《细胞—干细胞》杂志在线发表了这项成果。

Title: Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation

Author: Martin Bergert, Sergio Lembo, Sumana Sharma, Luigi Russo, Danica Milovanovi, Kristjan H. Gretarsson, Mandy Brmel, Pierre A. Neveu, Jamie A. Hackett, Evangelia Petsalaki, Alba Diz-Muoz

Issue&Volume: 2020-11-17

Abstract: Cell differentiation typically occurs with concomitant shape transitions to enable specialized functions. To adopt a different shape, cells need to change the mechanical properties of their surface. However, whether cell surface mechanics control the process of differentiation has been relatively unexplored. Here we show that membrane mechanics gate exit from naive pluripotency of mouse embryonic stem cells. By measuring membrane tension during early differentiation, we find that naive stem cells release their plasma membrane from the underlying actin cortex when transitioning to a primed state. By mechanically tethering the plasma membrane to the cortex by enhancing Ezrin activity or expressing a synthetic signaling-inert linker, we demonstrate that preventing this detachment forces stem cells to retain their naive pluripotent identity. We thus identify a decrease in membrane-to-cortex attachment as a new cell-intrinsic mechanism that is essential for stem cells to exit pluripotency.

DOI: 10.1016/j.stem.2020.10.017

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30533-6