俄罗斯国家血液学研究中心Grigory A. Efimov、荷兰埃因霍芬理工大学Mikhail Shugay等研究人员合作发现，SARS-CoV-2表位被多种人类T细胞受体所识别。2020年11月13日，国际知名学术期刊《免疫》在线发表了这一成果。

Title: SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors

Author: Alina S. Shomuradova, Murad S. Vagida, Savely A. Sheetikov, Ksenia V. Zornikova, Dmitry Kiryukhin, Aleksei Titov, Iuliia O. Peshkova, Alexandra Khmelevskaya, Dmitry V. Dianov, Maria Malasheva, Anton Shmelev, Yana Serdyuk, Dmitry V. Bagaev, Anastasia Pivnyuk, Dmitrii S. Shcherbinin, Alexandra V. Maleeva, Naina T. Shakirova, Artem Pilunov, Dmitry B. Malko, Ekaterina G. Khamaganova, Bella Biderman, Alexander Ivanov, Mikhail Shugay, Grigory A. Efimov

Issue&Volume: 2020-11-13

Abstract: Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic. Healthy donors examined during the pandemic exhibited increased numbers of SARS-CoV-2-specific T cells, but no humoral response. Their probable exposure to the virus resulted in either asymptomatic infection without antibody secretion, or activation of pre-existing immunity. In convalescent patients, we observed a public and diverse T cell response to SARS-CoV-2 epitopes, revealing T cell receptor (TCR) motifs with germline-encoded features. Bulk CD4+ and CD8+ T cell responses to the spike glycoprotein were mediated by groups of homologous TCRs, some of them shared across multiple donors. Overall, our results demonstrate that the T cell response to SARS-CoV-2, including the identified set of TCRs, can serve as a useful biomarker for surveying antiviral immunity.

DOI: 10.1016/j.immuni.2020.11.004

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30469-6