2020年11月12日，《细胞—代谢》杂志在线发表了山东大学易凡团队的最新成果。研究人员发现，JAML升高通过调节足细胞脂质代谢来促进糖尿病性肾脏疾病。

Title: Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism

Author: Yi Fu, Yu Sun, Mei Wang, Yunfeng Hou, Wei Huang, Di Zhou, Ziying Wang, Shuting Yang, Wei Tang, Junhui Zhen, Yujia Li, Xiaojie Wang, Min Liu, Yan Zhang, Baobao Wang, Guangyi Liu, Xiao Yu, Jinpeng Sun, Chun Zhang, Fan Yi

Issue&Volume: 2020-11-12

Abstract: Lipid accumulation in podocytes is a major determinant of diabetic kidney disease(DKD) and identification of potential therapeutic targets by mediating podocyte lipidmetabolism has clinical importance. This study was to elucidate the role of JAML (junctionaladhesion molecule-like protein) in the pathogenesis of DKD. We first confirmed theexpression of JAML in podocytes and found that podocyte-specific deletion of Jaml ameliorated podocyte injury and proteinuria in two different models of diabetic mice.We further demonstrated a novel role of JAML in regulating podocyte lipid metabolismthrough SIRT1-mediated SREBP1 signaling. Similar results were also found in mice withadriamycin-induced nephropathy. Importantly, we observed a higher expression of JAMLin glomeruli from subjects with DKD and other types of proteinuric kidney diseases,and the level of JAML was correlated with lipid accumulation and glomerular filtrationrate, suggesting that JAML may be an attractive therapeutic target for proteinurickidney disease.

DOI: 10.1016/j.cmet.2020.10.019

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30552-0