美国加州大学旧金山分校Aaron D. Tward团队揭示角质形成细胞对鼓膜维持的贡献。这一研究成果于2020年11月11日在线发表在国际学术期刊《细胞—干细胞》上。
Title: A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane
Author: Stacey M. Frumm, Shengyang Kevin Yu, Joseph Chang, Jordan A. Artichoker, Sonia M. Scaria, Katharine P. Lee, Lauren E. Byrnes, Julie B. Sneddon, Aaron D. Tward
Issue&Volume: 2020-11-11
Abstract: The tympanic membrane (TM) is critical for hearing and requires continuous clearingof cellular debris, but little is known about homeostatic mechanisms in the TM epidermis.Using single-cell RNA sequencing, lineage tracing, whole-organ explant, and live-cellimaging, we show that homeostatic TM epidermis is distinct from other epidermal sitesand has discrete proliferative zones with a three-dimensional hierarchy of multiplekeratinocyte populations. TM stem cells reside in a discrete location of the superiorTM and generate long-lived clones and committed progenitors (CPs). CP clones exhibitlateral migration, and their proliferative capacity is supported by Pdgfra+ fibroblasts,generating migratory but non-proliferative progeny. Single-cell sequencing of thehuman TM revealed similar cell types and transcriptional programming. Thus, duringhomeostasis, TM keratinocytes transit through a proliferative CP state and exhibitdirectional lateral migration. This work forms a foundation for understanding TM disordersand modeling keratinocyte biology.
DOI: 10.1016/j.stem.2020.10.006
Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30500-2
Cell Stem Cell:《细胞—干细胞》,创刊于2007年。隶属于细胞出版社,最新IF:21.464
官方网址:https://www.cell.com/cell-stem-cell/home
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