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研究人员揭示肯尼亚献血者中抗SARS-CoV-2 IgG抗体的血清阳性率
作者：小柯机器人 发布时间：2020/11/14 23:48:22

近日，肯尼亚KEMRI-Wellcome信托研究计划George M. Warimwe等研究人员揭示肯尼亚献血者中抗SARS-CoV-2 IgG抗体的血清阳性率。2020年11月11日，国际知名学术期刊《科学》在线发表了这一成果。

研究人员确定了2020年4月至6月在肯尼亚的献血者中抗SARS-CoV-2 IgG的患病率。粗血清阳性率为5.6％（174/3098）。经人口加权、测试性能调整的全国血清阳性率是4.3％（95％CI 2.9–5.8％），在城市县，蒙巴萨（8.0％）、内罗毕（7.3％）和基苏木（5.5％）中最高。SARS-CoV-2暴露比病例监测所揭示的更为广泛，这些结果将有助于指导肯尼亚及整个非洲的大流行应对。
 
据介绍，关于SARS-CoV-2在非洲的传播情况报道不多。肯尼亚于2020年3月12日报告了第一例SARS-CoV-2病例，预计会有大量病例和死亡，但到2020年7月31日，只有20,636例病例和341例死亡。但是，社区中SARS-CoV-2的暴露程度仍然未知。
 
附：英文原文

Title: Seroprevalence of anti–SARS-CoV-2 IgG antibodies in Kenyan blood donors

Author: Sophie Uyoga, Ifedayo M. O. Adetifa, Henry K. Karanja, James Nyagwange, James Tuju, Perpetual Wanjiku, Rashid Aman, Mercy Mwangangi, Patrick Amoth, Kadondi Kasera, Wangari Ng’ang’a, Charles Rombo, Christine Yegon, Khamisi Kithi, Elizabeth Odhiambo, Thomas Rotich, Irene Orgut, Sammy Kihara, Mark Otiende, Christian Bottomley, Zonia N. Mupe, Eunice W. Kagucia, Katherine E. Gallagher, Anthony Etyang, Shirine Voller, John N. Gitonga, Daisy Mugo, Charles N. Agoti, Edward Otieno, Leonard Ndwiga, Teresa Lambe, Daniel Wright, Edwine Barasa, Benjamin Tsofa, Philip Bejon, Lynette I. Ochola-Oyier, Ambrose Agweyu, J. Anthony G. Scott, George M. Warimwe

Issue&Volume: 2020/11/11

Abstract: The spread of SARS-CoV-2 in Africa is poorly described. The first case of SARS-CoV-2 in Kenya was reported on March 12, 2020 and an overwhelming number of cases and deaths were expected but by July 31, 2020 there were only 20,636 cases and 341 deaths. However, the extent of SARS-CoV-2 exposure in the community remains unknown. We determined the prevalence of anti–SARS-CoV-2 IgG among blood donors in Kenya in April-June 2020. Crude seroprevalence was 5.6% (174/3098). Population-weighted, test-performance-adjusted national seroprevalence was 4.3% (95% CI 2.9–5.8%) and was highest in urban counties, Mombasa (8.0%), Nairobi (7.3%) and Kisumu (5.5%). SARS-CoV-2 exposure is more extensive than indicated by case-based surveillance and these results will help guide the pandemic response in Kenya, and across Africa.

DOI: 10.1126/science.abe1916

Source: https://science.sciencemag.org/content/early/2020/11/10/science.abe1916

期刊信息
Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037