美国普渡大学化学系R Graham Cooks研究团队发现，玻璃颗粒可以催化固液界面上的Katrizky反应。 这一研究成果于2020年11月8日发表在《德国应用化学》上。

研究人员发现，当在玻璃容器中时，室温下本体溶液中发生的Katrizky反应明显比在塑料容器中快。值得注意的是，加入玻璃颗粒后该反应的速率提高了两个数量级以上，并且速率的增加和加入的玻璃的量呈线性关系。当将玻璃颗粒添加到悬浮液滴中时，研究人员亦观察到类似的现象，且反应加速更为明显。

有证据表明，玻璃起着催化剂的作用：它作为碱参与去质子化步骤，并以初始形态从反应混合物中回收。研究人员在这项研究中发现，反应加速是在两个不同的界面上发生的：一是气液界面，也就是众所周知的微滴造成的；二是固液界面，而这一加速似乎是一个新的现象。

附：英文原文

Title: Reaction Acceleration at Solid/Solution Interfaces: Katritzky Reaction Catalyzed by Glass Particles

Author: Yangjie Li, Tsdale Mehari, Zhenwei Wei, Yong Liu, R Graham Cooks

Issue&Volume: 2020/11/08

Abstract: The Katritzky reaction in bulk solution at room temperature is accelerated significantly by the surface of a glass container compared to a plastic container. Remarkably, the reaction rate is increased by more than two orders of magnitude upon the addition of glass particles with the rate increasing linearly with increasing amounts of glass. A similar phenomenon is observed when glass particles are added to levitated droplets, where large acceleration factors are seen. Evidence shows that glass acts as a catalyst: it participates as a base in the deprotonation step and is recovered unchanged from the reaction mixture. Reaction acceleration at two separate interfaces is recognized in this study: (i) air/solution phase acceleration, as is well known in microdroplets; (ii) solid/solution phase, where such acceleration appears to be a new phenomenon.

DOI: 10.1002/anie.202014613

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202014613