美国西奈山伊坎医学院Carlos Cordon-Cardo等研究人员发现，SARS-CoV-2强力中和抗体可持续数月。该项研究成果于2020年10月28日在线发表在《科学》杂志上。

Title: Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Author: Ania Wajnberg, Fatima Amanat, Adolfo Firpo, Deena R. Altman, Mark J. Bailey, Mayce Mansour, Meagan McMahon, Philip Meade, Damodara Rao Mendu, Kimberly Muellers, Daniel Stadlbauer, Kimberly Stone, Shirin Strohmeier, Viviana Simon, Judith Aberg, David L. Reich, Florian Krammer, Carlos Cordon-Cardo

Issue&Volume: 2020/10/28

Abstract: SARS-CoV-2 has caused a global pandemic with millions infected and numerous fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust IgG antibody responses against the viral spike protein, based on a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City. We also show that titers are relatively stable for at least a period approximating 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggests that more than 90% of seroconverters make detectible neutralizing antibody responses. These titers remain relatively stable for several months after infection.

DOI: 10.1126/science.abd7728

Source: https://science.sciencemag.org/content/early/2020/10/27/science.abd7728