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工程化的Fe–N掺杂石墨烯可模拟细胞中NADPH氧化酶的生物学功能
作者:小柯机器人 发布时间:2020/10/29 15:44:27

苏州大学Ruibin Li等研究人员合作发现,工程化的Fe–N掺杂石墨烯可模拟细胞中NADPH氧化酶的生物学功能。相关论文于2020年10月27日在线发表在《美国化学会志》上。

研究人员合成了一种Fe-N掺杂石墨烯(FeNGR)纳米材料,其可通过有效催化NADPH转化为NADP+并触发氧自由基的产生来模仿NADPH氧化酶(NOX)的活性。产生的FeNGR纳米酶具有与NOX相似的细胞分布,并能够通过催化超氧化物的产生并恢复免疫活性来模拟NOX缺乏细胞中的酶功能,这由明矾暴露时TNF-α、IL-1β和IL-6的产生所证明。
 
总体而言,这项研究发现了一种模仿NOX的合成材料(FeNGR),并证明了其在NOX缺乏细胞免疫激活中的生物学功能。
 
据了解,NOX作为跨膜酶复合物,可控制超氧化物的产生,从而在免疫信号通路中起重要作用。NOX失活可能引起免疫缺陷并引起慢性肉芽肿病(CGD)。因此,在缺乏氮氧化物的情况下,具有生物活性的合成材料具有类似于氮氧化物的活性,可作为治疗和/或预防的潜在方法。
 
附:英文原文

Title: Engineering Fe–N Doped Graphene to Mimic Biological Functions of NADPH Oxidase in Cells

Author: Di Wu, Jingkun Li, Shujuan Xu, Qianqian Xie, Yanxia Pan, Xi Liu, Ronglin Ma, Huizhen Zheng, Meng Gao, Weili Wang, Jia Li, Xiaoming Cai, Frédéric Jaouen, Ruibin Li

Issue&Volume: October 27, 2020

Abstract: NADPH oxidase (NOX) as a transmembrane enzyme complex controls the generation of superoxide that plays important roles in immune signaling pathway. NOX inactivation may elicit immunodeficiency and cause chronic granulomatous disease (CGD). Biocompatible synthetic materials with NOX-like activities would therefore be interesting as curative and/or preventive approaches in case of NOX deficiency. Herein, we synthesized a Fe–N doped graphene (FeNGR) nanomaterial that could mimic the activity of NOX by efficiently catalyzing the conversion of NADPH into NADP+ and triggering the generation of oxygen radicals. The resulting FeNGR nanozyme had similar cellular distribution to NOX and is able to mimic the enzyme function in NOX-deficient cells by catalyzing the generation of superoxide and retrieving the immune activity, evidenced by TNF-α, IL-1β, and IL-6 production in response to Alum exposure. Overall, our study discovered a synthetic material (FeNGR) to mimic NOX and demonstrated its biological function in immune activation of NOX-deficient cells.

DOI: 10.1021/jacs.0c08360

Source: https://pubs.acs.org/doi/10.1021/jacs.0c08360

 

期刊信息

JACS:《美国化学会志》,创刊于1879年。隶属于美国化学会,最新IF:14.612
官方网址:https://pubs.acs.org/journal/jacsat
投稿链接:https://acsparagonplus.acs.org/psweb/loginForm?code=1000