美国芝加哥大学Patrick C. Wilson课题组发现,多反应性中和B细胞为大流行性流感病毒提供防御。2020年10月22日,《免疫》杂志在线发表了这项成果。
Title: Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses
Author: Jenna J. Guthmiller, Linda Yu-Ling Lan, Monica L. Fernández-Quintero, Julianna Han, Henry A. Utset, Dalia J. Bitar, Natalie J. Hamel, Olivia Stovicek, Lei Li, Micah Tepora, Carole Henry, Karlynn E. Neu, Haley L. Dugan, Marta T. Borowska, Yao-Qing Chen, Sean T.H. Liu, Christopher T. Stamper, Nai-Ying Zheng, Min Huang, Anna-Karin E. Palm, Adolfo García-Sastre, Raffael Nachbagauer, Peter Palese, Lynda Coughlan, Florian Krammer, Andrew B. Ward, Klaus R. Liedl, Patrick C. Wilson
Issue&Volume: 2020-10-22
Abstract: Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than 500 monoclonal antibodies (mAbs) derived from B cells induced by numerous influenza virus vaccines and infections, we found mAbs targeting conserved neutralizing influenza virus hemagglutinin epitopes were polyreactive. Polyreactive mAbs were preferentially induced by novel viral exposures due to their broad viral binding breadth. Polyreactivity augmented mAb viral binding strength by increasing antibody flexibility, allowing for adaption to imperfectly conserved epitopes. Lastly, we found affinity-matured polyreactive B cells were typically derived from germline polyreactive B cells that were preferentially selected to participate in B cell responses over time. Together, our data reveal that polyreactivity is a beneficial feature of antibodies targeting conserved epitopes.
DOI: 10.1016/j.immuni.2020.10.005
Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30446-5
Immunity:《免疫》,创刊于1994年。隶属于细胞出版社,最新if:21.522
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