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杏仁核抑制神经元是情绪记忆的翻译位点
作者:小柯机器人 发布时间:2020/10/11 21:17:35

美国纽约大学Eric Klann和Prerana Shrestha团队合作取得新进展。他们发现杏仁核抑制神经元作为情绪记忆的翻译位点。这一研究成果于2020年10月7日发表在国际顶尖学术期刊《自然》上。

他们将交叉化学生成策略应用于小鼠中央外侧杏仁核的抑制性神经元,以阻断对真核生物起始因子4E(eIF4E)的消耗和真核生物起始因子2α(p-eIF2α)磷酸化敏感的细胞类型特异性翻译程序。他们显示在中枢外侧杏仁核中生长抑素表达抑制神经元的从头翻译,对于长期存储条件性威胁反应是必要的,而在中枢杏仁外侧中蛋白激酶Cδ表达抑制性神经元的从头翻译对于抑制响应安全因素条件是必要的。

他们的结果提供了在长期记忆巩固期间,从头蛋白合成在中央外侧杏仁核的不同抑制性神经元群体中的作用的见解。

据了解,为了在动态环境中生存,动物需要识别并适当响应发出危险信号的刺激。生存与否还取决于在预测没有威胁(安全)的刺激中抑制威胁响应。在动物学习如何灵活地对威胁预测因素和安全因素执行防御性任务的过程中,理解情绪记忆的生物学基础对于开发针对诸如创伤后应激障碍的记忆障碍治疗至关重要。中央外侧杏仁核是神经元回路中的重要节点,介导防御反应,并且是处理和存储威胁记忆的关键大脑区域。

附:英文原文

Title: Amygdala inhibitory neurons as loci for translation in emotional memories

Author: Prerana Shrestha, Zhe Shan, Maggie Mamcarz, Karen San Agustin Ruiz, Adam T. Zerihoun, Chien-Yu Juan, Pedro M. Herrero-Vidal, Jerry Pelletier, Nathaniel Heintz, Eric Klann

Issue&Volume: 2020-10-07

Abstract: To survive in a dynamic environment, animals need to identify and appropriately respond to stimuli that signal danger1. Survival also depends on suppressing the threat-response during a stimulus that predicts the absence of threat (safety)2,3,4,5. An understanding of the biological substrates of emotional memories during a task in which animals learn to flexibly execute defensive responses to a threat-predictive cue and a safety cue is critical for developing treatments for memory disorders such as post-traumatic stress disorder5. The centrolateral amygdala is an important node in the neuronal circuit that mediates defensive responses6,7,8,9, and a key brain area for processing and storing threat memories. Here we applied intersectional chemogenetic strategies to inhibitory neurons in the centrolateral amygdala of mice to block cell-type-specific translation programs that are sensitive to depletion of eukaryotic initiation factor 4E (eIF4E) and phosphorylation of eukaryotic initiation factor 2α (p-eIF2α). We show that de novo translation in somatostatin-expressing inhibitory neurons in the centrolateral amygdala is necessary for the long-term storage of conditioned-threat responses, whereas de novo translation in protein kinase Cδ-expressing inhibitory neurons in the centrolateral amygdala is necessary for the inhibition of a conditioned response to a safety cue. Our results provide insight into the role of de novo protein synthesis in distinct inhibitory neuron populations in the centrolateral amygdala during the consolidation of long-term memories.

DOI: 10.1038/s41586-020-2793-8

Source: https://www.nature.com/articles/s41586-020-2793-8

期刊信息

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html