法国巴斯德研究所Jerome Gros、巴黎文理研究大学Francis Corson等研究人员合作发现，张力环驱动组织流动来塑造羊膜胚胎原肠化。2020年1月24日，国际知名学术期刊《科学》发表了这一成果。

Title: A tensile ring drives tissue flows to shape the gastrulating amniote embryo

Author: Mehdi Saadaoui, Didier Rocancourt, Julian Roussel, Francis Corson, Jerome Gros

Issue&Volume: 2020/01/24

Abstract: Tissue morphogenesis is driven by local cellular deformations that are powered by contractile actomyosin networks. How localized forces are transmitted across tissues to shape them at a mesoscopic scale is still unclear. Analyzing gastrulation in entire avian embryos, we show that it is driven by the graded contraction of a large-scale supracellular actomyosin ring at the margin between the embryonic and extraembryonic territories. The propagation of these forces is enabled by a fluid-like response of the epithelial embryonic disk, which depends on cell division. A simple model of fluid motion entrained by a tensile ring quantitatively captures the vortex-like “polonaise” movements that accompany the formation of the primitive streak. The geometry of the early embryo thus arises from the transmission of active forces generated along its boundary.

DOI: 10.1126/science.aaw1965

Source: https://science.sciencemag.org/content/367/6476/453