美国加州大学圣地亚哥分校Eniko Sajti等研究人员的一项最新工作揭示了肺中髓系细胞多样性的转录组和表观遗传机制。2020年1月20日，《自然—免疫学》在线发表了这项成果。

Title: Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung

Author: Eniko Sajti, Verena M. Link, Zhengyu Ouyang, Nathanael J. Spann, Emma Westin, Casey E. Romanoski, Gregory J. Fonseca, Lawrence S. Prince, Christopher K. Glass

Issue&Volume: 2020-01-20

Abstract: The lung is inhabited by resident alveolar and interstitial macrophages as well as monocytic cells that survey lung tissues. Each cell type plays distinct functional roles under homeostatic and inflammatory conditions, but mechanisms establishing their molecular identities and functional potential remain poorly understood. In the present study, systematic evaluation of transcriptomes and open chromatin of alveolar macrophages (AMs), interstitial macrophages (IMs) and lung monocytes from two mouse strains enabled inference of common and cell-specific transcriptional regulators. We provide evidence that these factors drive selection of regulatory landscapes that specify distinct phenotypes of AMs and IMs and entrain qualitatively different responses to toll-like receptor 4 signaling in vivo. These studies reveal a striking divergence in a fundamental innate immune response pathway in AMs and establish a framework for further understanding macrophage diversity in the lung.

DOI: 10.1038/s41590-019-0582-z

Source: https://www.nature.com/articles/s41590-019-0582-z