瑞士弗雷德里-希米歇尔生物医学研究所Rainer W. Friedrich小组的一项最新研究发现,气味表征的增白通过嗅球来实现。这一研究成果2020年1月20日在线发表在国际学术期刊《自然—神经科学》上。
Title: Whitening of odor representations by the wiring diagram of the olfactory bulb
Author: Adrian A. Wanner, Rainer W. Friedrich
Issue&Volume: 2020-01-20
Abstract: Neuronal computations underlying higher brain functions depend on synaptic interactions among specific neurons. A mechanistic understanding of such computations requires wiring diagrams of neuronal networks. In this study, we examined how the olfactory bulb (OB) performs ‘whitening’, a fundamental computation that decorrelates activity patterns and supports their classification by memory networks. We measured odor-evoked activity in the OB of a zebrafish larva and subsequently reconstructed the complete wiring diagram by volumetric electron microscopy. The resulting functional connectome revealed an over-representation of multisynaptic connectivity motifs that mediate reciprocal inhibition between neurons with similar tuning. This connectivity suppressed redundant responses and was necessary and sufficient to reproduce whitening in simulations. Whitening of odor representations is therefore mediated by higher-order structure in the wiring diagram that is adapted to natural input patterns.
DOI: 10.1038/s41593-019-0576-z
Source: https://www.nature.com/articles/s41593-019-0576-z
Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新if:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex