美国埃默里大学医学院Jacob E. Kohlmeier小组的一项最新研究表明，环境因素调节呼吸道驻留记忆CD8+T细胞的表观遗传重编程。该研究2020年1月17日在线发表于国际一流学术期刊《自然—免疫学》。
Title: Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8 + T cells
Author: Sarah L. Hayward, Christopher D. Scharer, Emily K. Cartwright, Shiki Takamura, Zheng-Rong Tiger Li, Jeremy M. Boss, Jacob E. Kohlmeier
Abstract: Tissue-resident memory T cells (TRM cells) are critical for cellular immunity to respiratory pathogens and reside in both the airways and the interstitium. In the present study, we found that the airway environment drove transcriptional and epigenetic changes that specifically regulated the cytolytic functions of airway TRM cells and promoted apoptosis due to amino acid starvation and activation of the integrated stress response. Comparison of airway TRM cells and splenic effector-memory T cells transferred into the airways indicated that the environment was necessary to activate these pathways, but did not induce TRM cell lineage reprogramming. Importantly, activation of the integrated stress response was reversed in airway TRM cells placed in a nutrient-rich environment. Our data defined the genetic programs of distinct lung TRM cell populations and show that local environmental cues altered airway TRM cells to limit cytolytic function and promote cell death, which ultimately leads to fewer TRM cells in the lung.