美国耶鲁大学医学院Yibing Qyang团队取得一项成果，他们利用人类iPSC产生了具有优良机械强度的组织工程化血管移植物。2020年1月16日，《细胞—干细胞》杂志在线发表了这项成果。

Title: Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs

Author: Jiesi Luo, Lingfeng Qin, Liping Zhao, Liqiong Gui, Matthew W. Ellis, Yan Huang, Mehmet H. Kural, J. Alexander Clark, Shun Ono, Juan Wang, Yifan Yuan, Shang-Min Zhang, Xiaoqiang Cong, Guangxin Li, Muhammad Riaz, Colleen Lopez, Akitsu Hotta, Stuart Campbell, George Tellides, Alan Dardik, Laura E. Niklason, Yibing Qyang

Issue&Volume: January 16, 2020

Abstract: Vascular smooth muscle cells (VSMCs) can be derived in large numbers from human inducedpluripotent stem cells (hiPSCs) for producing tissue-engineered vascular grafts (TEVGs).However, hiPSC-derived TEVGs are hampered by low mechanical strength and significantradial dilation after implantation. Here, we report generation of hiPSC-derived TEVGswith mechanical strength comparable to native vessels used in arterial bypass graftsby utilizing biodegradable scaffolds, incremental pulsatile stretching, and optimalculture conditions. Following implantation into a rat aortic model, hiPSC-derivedTEVGs show excellent patency without luminal dilation and effectively maintain mechanicaland contractile function. This study provides a foundation for future production ofnon-immunogenic, cellularized hiPSC-derived TEVGs composed of allogenic vascular cells,potentially serving needs to a considerable number of patients whose dysfunctionalvascular cells preclude TEVG generation via other methods.

DOI: 10.1016/j.stem.2019.12.012

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30570-3