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DA神经元与奖励和运动有关
作者:小柯机器人 发布时间:2020/1/15 14:02:10

美国加州大学洛杉矶分校Sotiris C. Masmanidis研究组发现,DA神经元与奖励和运动有关。该项研究成果在线发表在2020年1月13日的《自然—神经科学》上。

在这项研究中,他们通过参数化巴甫洛夫式条件反射事件中的光遗传学操纵的时间,并检查在奖励之前对预期舔食的影响,来解码这些功能。在奖励后阶段抑制腹侧被盖区和黑质致密部中脑多巴胺(DA)神经元的行为效果要比在任务奖励前阶段抑制显著增大。此外,DA神经元对行为的贡献与奖励后经过的时间成线性降低关系。总之,这些结果表明,DA神经元在时间上的作用受到限制,主要与加强刺激与奖赏的关联有关,并表明直接产生运动的功能相对来说不那么重要。

据了解, DA神经元编码与奖励和运动有关的事件,并与奖励过程以及运动有关。因此,解开DA神经元在增强运动和产生运动中的作用是具有挑战性的,并引起了持久的争议。

附:英文原文

Title: Temporally restricted dopaminergic control of reward-conditioned movements

Author: Kwang Lee, Leslie D. Claar, Ayaka Hachisuka, Konstantin I. Bakhurin, Jacquelyn Nguyen, Jeremy M. Trott, Jay L. Gill, Sotiris C. Masmanidis

Issue&Volume: 2020-01-13

Abstract: Midbrain dopamine (DA) neurons encode both reward- and movement-related events and are implicated in disorders of reward processing as well as movement. Consequently, disentangling the contribution of DA neurons in reinforcing versus generating movements is challenging and has led to lasting controversy. In this study, we dissociated these functions by parametrically varying the timing of optogenetic manipulations in a Pavlovian conditioning task and examining the influence on anticipatory licking before reward delivery. Inhibiting both ventral tegmental area and substantia nigra pars compacta DA neurons in the post-reward period had a significantly greater behavioral effect than inhibition in the pre-reward period of the task. Furthermore, the contribution of DA neurons to behavior decreased linearly as a function of elapsed time after reward. Together, the results indicate a temporally restricted role of DA neurons primarily related to reinforcing stimulus–reward associations and suggest that directly generating movements is a comparatively less important function.

DOI: 10.1038/s41593-019-0567-0

Source: https://www.nature.com/articles/s41593-019-0567-0

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新if:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex