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收入水平影响铅接触风险及儿童脑发育
作者:小柯机器人 发布时间:2020/1/15 12:54:21

美国南加州大学Elizabeth R. Sowell课题组研究发现,铅接触风险和家庭收入与儿童大脑预后关系。该研究2020年1月13日在线发表于国际学术期刊《自然—医学》。

他们检查了9712名9岁和10岁儿童的大脑结构、认知,铅接触风险的地理编码度量和社会人口统计学特征之间的横断面关联。他们表示,在普查区中来自低收入家庭比高收入家庭的儿童在高铅风险生活的负相关性更强。随着接触风险的增加,来自低收入家庭的儿童表现出较低的认知测验得分,表现出较小的皮质体积和较小的皮质表面积。降低与铅接触风险相关的环境损害可能会给遭受更多环境逆境的儿童带来更大的好处,进一步了解与铅接触风险高相关的因素对于改善儿童的此类结局至关重要。

据了解,社会经济因素影响大脑的发育和结构,但是大多数研究都忽略了损害发育的神经毒性损害,例如铅接触。儿童接触最低的可测量浓度的铅可以影响认知发育,但对其在儿童时期对大脑发育的影响知之甚少。

附:英文原文

Title: Association of lead-exposure risk and family income with childhood brain outcomes

Author: Andrew T. Marshall, Samantha Betts, Eric C. Kan, Rob McConnell, Bruce P. Lanphear, Elizabeth R. Sowell

Issue&Volume: 2020/01

Abstract: Socioeconomic factors influence brain development and structure, but most studies have overlooked neurotoxic insults that impair development, such as lead exposure. Childhood lead exposure affects cognitive development at the lowest measurable concentrations, but little is known about its impact on brain development during childhood. We examined cross-sectional associations among brain structure, cognition, geocoded measures of the risk of lead exposure and sociodemographic characteristics in 9,712 9- and 10-year-old children. Here we show stronger negative associations of living in high-lead-risk census tracts in children from lower- versus higher-income families. With increasing risk of exposure, children from lower-income families exhibited lower cognitive test scores, smaller cortical volume and smaller cortical surface area. Reducing environmental insults associated with lead-exposure risk might confer greater benefit to children experiencing more environmental adversity, and further understanding of the factors associated with high lead-exposure risk will be critical for improving such outcomes in children. Cross-sectional analysis of data from the Adolescent Brain Cognitive Development Study shows that children from families with low income are at increased risk of cognitive impairment associated with high lead-exposure risk when compared with children from families with high income.

DOI: 10.1038/s41591-019-0713-y

Source:https://www.nature.com/articles/s41591-019-0713-y

期刊信息

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:30.641
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex