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研究揭示流感如何促进肺部免疫
作者:小柯机器人 发布时间:2020/1/15 11:29:43

英国弗朗西斯·克里克研究所Andreas Wack课题组的研究显示,流感诱导的单核细胞衍生肺泡巨噬细胞可以发挥持续的抗菌功能。相关论文在线发表在2020年1月13日的《自然—免疫学》上。

研究人员发现在清除流感病毒和恢复1个月之后,由于单核细胞衍生的肺泡巨噬细胞(AM)可以更好地保护小鼠免受肺炎链球菌感染,这些衍生的AM可以产生更多的白介素6。流行性感冒诱导的单核细胞衍生的AM具有类似于驻留AM的表面特征,但具有与驻留AM不同的独特功能、转录和表观遗传特征。相比之下,经过流感病毒的驻留AM仍然与初始AM相似。因此,流感会改变AM类群的组成,以提供长久的抗菌保护。单核细胞衍生的AMs会随着时间的推移而持续存在,但会失去其保护性。该研究结果有助于了解人类生活中常见的短暂呼吸道感染如何通过单核细胞衍生招募的AM来持久的改善肺部免疫。

据介绍,尽管流感在流行病学和临床都具有重要性,但尚不清楚它对肺部免疫的长期作用。

附:英文原文

Title: Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Author: Helena Aegerter, Justina Kulikauskaite, Stefania Crotta, Harshil Patel, Gavin Kelly, Edith M. Hessel, Matthias Mack, Soren Beinke, Andreas Wack

Issue&Volume: 2020-01-13

Abstract: Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages (AMs) that produce increased interleukin-6. Influenza-induced monocyte-derived AMs have a surface phenotype similar to resident AMs but display a unique functional, transcriptional and epigenetic profile that is distinct from resident AMs. In contrast, influenza-experienced resident AMs remain largely similar to naive AMs. Thus, influenza changes the composition of the AM population to provide prolonged antibacterial protection. Monocyte-derived AMs persist over time but lose their protective profile. Our results help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.

DOI: 10.1038/s41590-019-0568-x

Source: https://www.nature.com/articles/s41590-019-0568-x

期刊信息

Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:23.53
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex