英国牛津大学Elena Seiradake与德国马普神经生物学研究所Rüdiger Klein等研究人员合作揭示了，在迁移神经元排斥引导中Teneurin-Latrophilin相互作用的结构基础。相关论文于2020年1月9日在线发表于国际学术期刊《细胞》。

研究人员表示，Teneurins是古老的后生动物细胞粘附受体，可控制高等动物的大脑发育和神经元连接。细胞外C末端结合粘附GPCR Latrophilin，形成具有突触功能的跨细胞复合物。但是，Teneurins、Latrophilins和FLRT蛋白也在小鼠皮质细胞迁移的早期发育阶段表达。

附：英文原文

Title: Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

Author: Daniel del Toro, Maria A. Carrasquero-Ordaz, Amy Chu, Tobias Ruff, Meriam Shahin, Verity A. Jackson, Matthieu Chavent, Miguel Berbeira-Santana, Goenuel Seyit-Bremer, Sara Brignani, Rainer Kaufmann, Edward Lowe, Rüdiger Klein, Elena Seiradake

Issue&Volume: January 9, 2020

Abstract: Teneurins are ancient metazoan cell adhesion receptors that control brain development and neuronal wiring in higher animals. The extracellular C terminus binds the adhesion GPCR Latrophilin, forming a trans-cellular complex with synaptogenic functions. However, Teneurins, Latrophilins, and FLRT proteins are also expressed during murine cortical cell migration at earlier developmental stages. Here, we present crystal structures of Teneurin-Latrophilin complexes that reveal how the lectin and olfactomedin domains of Latrophilin bind across a spiraling beta-barrel domain of Teneurin, the YD shell. We couple structure-based protein engineering to biophysical analysis, cell migration assays, and in utero electroporation experiments to probe the importance of the interaction in cortical neuron migration. We show that binding of Latrophilins to Teneurins and FLRTs directs the migration of neurons using a contact repulsion-dependent mechanism. The effect is observed with cell bodies and small neurites rather than their processes. The results exemplify how a structure-encoded synaptogenic protein complex is also used for repulsive cell guidance.

DOI: 10.1016/j.cell.2019.12.014

Source: https://www.cell.com/cell/fulltext/S0092-8674(19)31376-5