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滤泡辅助性T细胞新亚型获鉴定
作者:小柯机器人 发布时间:2019/8/30 14:07:38

美国耶鲁大学医学院Stephanie C. Eisenbarth和康涅狄格大学Adam Williams团队合作取得一项新进展。他们鉴定到一类滤泡辅助性T细胞(TFH)亚群,其能够促进过敏性的免疫球蛋白E(IgE)的产生。相关论文发表在2019年8月30日出版的《科学》杂志上。

研究人员在带有针对过敏原的IgE的小鼠和人类中鉴定到一种罕见的产生IL-13的TFH细胞,但是当过敏原特异性IgE不存在或仅具有低亲和力时则没有这一类群的细胞。这些“TFH13”细胞具有不寻常的细胞因子谱(IL-13hiIL-4hiIL-5hiIL-21lo)并共表达转录因子BCL6和GATA3。TFH13细胞对于产生高亲和力的IgE以及随后的过敏原诱导的过敏反应是必需的。阻断TFH13细胞是改善过敏反应的一个可能的治疗靶标。

研究人员表示,高亲和力IgE的交联会导致危及生命的过敏反应。然而,诱导B细胞响应过敏原产生IgE的细胞机制仍然知之甚少。TFH指导由B细胞产生的抗体亲和力和同种型。虽然TFH细胞来源的白细胞介素-4(IL-4)是IgE产生所必需的,但这还不足够。

附:英文原文

Author: Uthaman Gowthaman, Jennifer S. Chen, Biyan Zhang, William F. Flynn, Yisi Lu, Wenzhi Song, Julie Joseph, Jake A. Gertie, Lan Xu, Magalie A. Collet, Jessica D. S. Grassmann, Tregony Simoneau, David Chiang, M. Cecilia Berin, Joseph E. Craft, Jason S. Weinstein, Adam Williams, Stephanie C. Eisenbarth

Issue&Volume: Volume 365 Issue 6456, 2019/08/30

Abstract: Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction anaphylaxis. Yet the cellular mechanisms that induce B cells to produce IgE in response to allergens remain poorly understood. T follicular helper (TFH) cells direct the affinity and isotype of antibodies produced by B cells. Although TFH cell–derived interleukin-4 (IL-4) is necessary for IgE production, it is not sufficient. We report a rare population of IL-13–producing TFH cells present in mice and humans with IgE to allergens, but not when allergen-specific IgE was absent or only low-affinity. These “TFH13” cells have an unusual cytokine profile (IL-13hiIL-4hiIL-5hiIL-21lo) and coexpress the transcription factors BCL6 and GATA3. TFH13 cells are required for production of high- but not low-affinity IgE and subsequent allergen-induced anaphylaxis. Blocking TFH13 cells may represent an alternative therapeutic target to ameliorate anaphylaxis.

DOI: 10.1126/science.aaw6433

Source: https://science.sciencemag.org/content/365/6456/eaaw6433

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037