奥地利格拉茨大学的Frank Madeo团队近日发现，在健康非肥胖的人群中，隔日禁食能够改善衰老的生理和分子标志物。2019年8月27日，《细胞—代谢》在线发表了这项成果。

在一项随机对照试验研究中，研究人员发现为期4周的严格隔日禁食（ADF）改善了健康中年人的一般健康指标，同时平均降低了37％的卡路里。即使在超过6个月后也没有发生不良反应。ADF改善心血管标志物，减少脂肪量（特别是躯干脂肪），改善脂肪与瘦肉率，并增加β-羟基丁酸盐，即使在非禁食日也是如此。在禁食日，促老化的氨基酸蛋氨酸等被定期耗尽，而多不饱和脂肪酸则升高。研究人员发现在长期ADF后，sICAM-1（一种与年龄相关的炎症标记物）、低密度脂蛋白和代谢调节剂三碘甲状腺原氨酸水平降低。这些结果揭示了ADF的生理影响并支持其安全性。ADF最终可能成为临床相关的干预措施。

据悉，热量限制和间歇性禁食能够延长模式生物的寿命和健康，但是它们对人类的影响研究较少。

附：英文原文

Title: Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Author: Slaven Stekovic, Sebastian J. Hofer, Norbert Tripolt, Miguel A. Aon, Philipp Royer, Lukas Pein, Julia T. Stadler, Tobias Pendl, Barbara Prietl, Jasmin Url, Sabrina Schroeder, Jelena Tadic, Tobias Eisenberg, Christoph Magnes, Michael Stumpe, Elmar Zuegner, Natalie Bordag, Regina Riedl, Albrecht Schmidt, Ewald Kolesnik, Nicolas Verheyen, Anna Springer, Tobias Madl, Frank Sinner, Rafael de Cabo, Guido Kroemer, Barbara Obermayer-Pietsch, Jom Dengjel, Harald Sourij, Thomas R. Pieber, Frank Madeo

Issue&Volume: 27 August 2019

Abstract: Caloric restriction and intermittent fasting are known to prolong life- and healthspan in model organisms, while their effects on humans are less well studied. In a randomized controlled trial study (ClinicalTrials.gov identifier: NCT02673515), we show that 4 weeks of strict alternate day fasting (ADF) improved markers of general health in healthy, middle-aged humans while causing a 37% calorie reduction on average. No adverse effects occurred even after >6 months. ADF improved cardiovascular markers, reduced fat mass (particularly the trunk fat), improving the fat-to-lean ratio, and increased β-hydroxybutyrate, even on non-fasting days. On fasting days, the pro-aging amino-acid methionine, among others, was periodically depleted, while polyunsaturated fatty acids were elevated. We found reduced levels sICAM-1 (an age-associated inflammatory marker), low-density lipoprotein, and the metabolic regulator triiodothyronine after long-term ADF. These results shed light on the physiological impact of ADF and supports its safety. ADF could eventually become a clinically relevant intervention.

DOI: https://doi.org/10.1016/j.cmet.2019.07.016

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30429-2