美国加州大学圣地亚哥分校Pam R. Taub和索尔克生物研究所Satchidananda Panda研究组合作，最新发现10小时限时进食可以降低代谢综合征患者的体重、血压和致动脉粥样血脂。该研究2019年12月5日在线发表在《细胞—代谢》上。

在一项单组配对样本的试验中，19名患有代谢综合征并且其基线平均每日进食时间≥14小时的参与者，接受了持续12周的10小时限时饮食（TRE）（所有饮食在自我选择的10小时窗口内完成），其中大部分患者接受了他汀类和/或降压治疗。研究发现，这种TRE干预可改善代谢综合征患者接受标准药物治疗（包括高他汀类药物和抗高血压药物的使用）的心脏代谢健康。TRE可能是一种强大的生活方式干预措施，可以添加到标准的医学实践中以治疗代谢综合征。

据介绍，在动物模型中，限时喂养（TRF）可以预防和逆转代谢疾病。在人体试验中，限时饮食（TRE）降低了健康人群的代谢疾病风险。然而，代谢综合症患者经常接受药物治疗，并且从未在动物模型或人类中测试过TRE是否可以与药物治疗协同发挥作用。线粒体丙酮酸载体调控肿瘤发生。

附：英文原文

Title: Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Author: Michael J. Wilkinson, Emily N.C. Manoogian, Adena Zadourian, Hannah Lo, Savannah Fakhouri, Azarin Shoghi, Xinran Wang, Jason G. Fleischer, Saket Navlakha, Satchidananda Panda, Pam R. Taub

Issue&Volume: December 05, 2019

Abstract: In animal models, time-restricted feeding (TRF) can prevent and reverse aspects ofmetabolic diseases. Time-restricted eating (TRE) in human pilot studies reduces therisks of metabolic diseases in otherwise healthy individuals. However, patients withdiagnosed metabolic syndrome often undergo pharmacotherapy, and it has never beentested whether TRE can act synergistically with pharmacotherapy in animal models orhumans. In a single-arm, paired-sample trial, 19 participants with metabolic syndromeand a baseline mean daily eating window of ≥14 h, the majority of whom were on a statinand/or antihypertensive therapy, underwent 10 h of TRE (all dietary intake withina consistent self-selected 10 h window) for 12 weeks. We found this TRE interventionimproves cardiometabolic health for patients with metabolic syndrome receiving standardmedical care including high rates of statin and anti-hypertensive use. TRE is a potentiallypowerful lifestyle intervention that can be added to standard medical practice totreat metabolic syndrome.

DOI: 10.1016/j.cmet.2019.11.004

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30611-4