美国西北大学D. James Surmeier研究组发现多巴胺（DA）通过单胺氧化酶（MAO）线粒体穿梭代谢来激活电子传输链。2019年12月16日，国际学术期刊《自然—神经科学》发表了这一成果。

他们表示，DA的MAO代谢不会增加胞质中的H2O2，但会导致线粒体电子转运链（ETC）活性。这取决于MAO锚定到线粒体外膜上，并使电子通过膜间空间穿梭，以支持阶段性DA释放的生物能需求。

据了解， MAO代谢胞质DA，从而限制了自身氧化，但也被认为会产生胞质过氧化氢（H2O2）。

附：英文原文

Title: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Author: Steven M. Graves, Zhong Xie, Kristen A. Stout, Enrico Zampese, Lena F. Burbulla, Jean C. Shih, Jyothisri Kondapalli, Tomasso Patriarchi, Lin Tian, Lars Brichta, Paul Greengard, Dimitri Krainc, Paul T. Schumacker, D. James Surmeier

Issue&Volume: 2019-12-16

Abstract: Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that MAO metabolism of DA does not increase cytosolic H2O2 but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.

DOI: 10.1038/s41593-019-0556-3

Source: https://www.nature.com/articles/s41593-019-0556-3