瑞士洛桑联邦理工学院Johan Auwerx团队总结了线粒体细胞通讯与健康、疾病之间的关系。相关论文2019年11月15日发表于国际学术期刊《科学》上。

他们回顾了有关促成这些线粒体细胞通讯网络的各种机制的最新发现，涵盖了从经过充分研究的信使分子到微核遗传相互作用的范围。基于这些结果和发现，他们提倡对微细胞相互作用持以广泛而包容的观点，这可能会对生理、病理和进化过程产生深远影响。

研究人员表示，在整个动物界中，线粒体是唯一保留其自身基因组以及转录和翻译机器的细胞器，而这些都是能量收集所必需的。线粒体已经建立了一个复杂的通讯网络，可以与细胞需求以及核转录程序保持一致，并减轻线粒体功能障碍。

附：英文原文

Title: Mitocellular communication: Shaping health and disease

Author: Adrienne Mottis, Sébastien Herzig, Johan Auwerx

Issue&Volume: 2019/11/15

Abstract: Throughout the animal kingdom, mitochondria are the only organelles that retain their own genome and the transcription and translation machineries that are all essential for energy harvesting. Mitochondria have developed a complex communication network, allowing them to stay in tune with cellular needs and nuclear transcriptional programs and to alleviate mitochondrial dysfunction. Here, we review recent findings on the wide array of mechanisms that contribute to these mitocellular communication networks, spanning from well-studied messenger molecules to mitonuclear genetic interactions. Based on these observations and developments, we advocate a broad and inclusive view on mitocellular interactions, which can have profound impacts on physiological, pathological, and evolutionary processes.

DOI: 10.1126/science.aax3768

Source:https://science.sciencemag.org/content/366/6467/827