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科学家展望神经科学与神经胶质瘤研究的未来
作者:小柯机器人 发布时间:2019/11/14 13:07:48

德国海德堡大学医院Frank Winkler等研究人员,总结并展望了神经科学和神经胶质瘤生物学交叉的未来发展方向。该综述2019年11月12日在线发表于国际学术期刊《自然—神经科学》。

研究人员表示,大脑中神经元和神经胶质网络的建立取决于神经祖细胞的活动,这些活动受细胞内在机制、与局部微环境的相互作用和远距离信号传导的影响。神经科学的进步有助于确定中枢神经系统发展的关键因素。同时,近年来的研究增加了人们对原发性脑肿瘤发生和发展中分子和细胞因子的了解。为了增殖,神经胶质瘤细胞利用在正常的中枢神经系统祖细胞以及正常的神经递质信号传导中活跃的途径。此外,无法治愈的神经胶质瘤的肿瘤细胞整合到通信的多细胞网络中,并通过神经突样细胞突起相互连接。

研究人员讨论中枢神经系统发育、组织和功能与神经胶质瘤进展和恶性肿瘤具有许多共同特征的证据。这些包括细胞用于增殖和迁移、与其微环境相互作用并整合到多细胞网络中的机制。在这篇综述中,神经科学和神经肿瘤学领域之间正在出现的交叉点指出了新的研究方向和新的治疗机会。

附:英文原文

Title: Emerging intersections between neuroscience and glioma biology

Author: Erik Jung, Julieta Alfonso, Matthias Osswald, Hannah Monyer, Wolfgang Wick, Frank Winkler

Issue&Volume: 2019-11-12

Abstract: The establishment of neuronal and glial networks in the brain depends on the activities of neural progenitors, which are influenced by cell-intrinsic mechanisms, interactions with the local microenvironment and long-range signaling. Progress in neuroscience has helped identify key factors in CNS development. In parallel, studies in recent years have increased our understanding of molecular and cellular factors in the development and growth of primary brain tumors. To thrive, glioma cells exploit pathways that are active in normal CNS progenitor cells, as well as in normal neurotransmitter signaling. Furthermore, tumor cells of incurable gliomas integrate into communicating multicellular networks, where they are interconnected through neurite-like cellular protrusions. In this Review, we discuss evidence that CNS development, organization and function share a number of common features with glioma progression and malignancy. These include mechanisms used by cells to proliferate and migrate, interact with their microenvironment and integrate into multicellular networks. The emerging intersections between the fields of neuroscience and neuro-oncology considered in this review point to new research directions and novel therapeutic opportunities.

DOI: 10.1038/s41593-019-0540-y

Source: https://www.nature.com/articles/s41593-019-0540-y

期刊信息

Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新if:21.126
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex